Product image of Pamidronate Disodique Hospira (Pamidronate Disodium) supplied by GNH India

Pamidronate Disodique Hospira

Active Ingredient:
Pamidronate Disodium
Origin:
EU

Pamidronate Disodique Hospira (Pamidronate Disodium)

Pamidronate Disodium, the active ingredient in Pamidronate Disodique Hospira, is a bisphosphonate presented as an injectable solution for intravenous use. It is used to treat disorders of bone metabolism, particularly in patients with cancer‑related bone disease and in those requiring renal protection during certain imaging procedures.

GNH India supplies Pamidronate Disodique Hospira as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and oncology centres worldwide.

Manufacturer / TM Owner

Hospira Benelux

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Indications & Clinical Uses

Pamidronate Disodium is employed in several bone‑related clinical pathways, primarily targeting abnormal calcium turnover.

  • Hypercalcaemia of malignancy: reduces the elevated serum calcium level.
  • Bone metastases from solid tumours: helps to lessen bone pain and lower the risk of skeletal‑related events.
  • Osteolytic lesions in multiple myeloma: stabilises bone structure and reduces fracture risk.
  • Prevention of renal toxicity during radiopharmaceutical imaging: protects kidney function when certain diagnostic agents are used.

How It Works

  • Pamidronate binds to hydroxyapatite crystals on bone surfaces, where it is taken up by osteoclasts during bone resorption. The drug inhibits farnesyl pyrophosphate synthase within the osteoclast, disrupting the mevalonate pathway and preventing the prenylation of essential proteins, which leads to reduced osteoclast activity and ultimately decreases bone turnover.

Side Effects

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Common Side Effects

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Precautions & Warnings

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Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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