Panadol Duo (Ibuprofen, Paracetamol)

Panadol Duo combines ibuprofen and paracetamol to provide analgesic and antipyretic relief across several common conditions.

• Headache: reduces pain intensity and associated discomfort.
• Dental pain: alleviates post‑extraction or procedural pain.
• Musculoskeletal pain: eases aches from strains, sprains and minor injuries.
• Fever: lowers elevated body temperature in acute febrile states.
• Menstrual discomfort: diminishes cramping and associated pain.

• Ibuprofen inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing prostaglandin synthesis that mediates pain, fever and inflammation. Paracetamol acts centrally by inhibiting a variant of the COX enzyme and modulating serotonergic pathways, providing additional analgesic and antipyretic effects without significant peripheral anti‑inflammatory activity.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

• Nausea: mild stomach upset that may occur after dosing.
• Dyspepsia: occasional indigestion or heartburn.
• Headache: transient headache unrelated to the condition being treated.
• Dizziness: brief episodes of light‑headedness.
• Rash: mild skin redness or itching.

Serious or Rare Side Effects

• Gastrointestinal bleeding: black or tarry stools, vomiting blood.
• Liver injury: jaundice, dark urine, elevated liver enzymes.
• Severe skin reactions: Stevens‑Johnson syndrome, toxic epidermal necrolysis.
• Anaphylaxis: rapid onset of swelling, difficulty breathing, hypotension.

Before using Panadol Duo, consider the following safety measures:

• Assess renal function: patients with impaired kidneys may require dose adjustment.
• Evaluate hepatic health: avoid use in severe liver disease.
• Monitor gastrointestinal risk: history of ulcers or bleeding increases caution.
• Use caution in pregnancy: limit exposure and consult a healthcare professional.
• Avoid in children under the recommended age without medical advice.
• Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Panadol Duo can interact with several medicines; awareness helps prevent adverse events.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of bleeding.
• High‑dose aspirin: additive gastrointestinal toxicity.
• Certain antihypertensives (ACE inhibitors, ARBs): may reduce renal perfusion.

Moderate Interactions (Monitor Closely)

• Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding risk.
• Lithium: ibuprofen may raise serum lithium levels.
• Methotrexate: reduced clearance may increase toxicity.