Product image of Panadol Extend (Paracetamol) supplied by GNH India

Panadol Extend

Active Ingredient:
Paracetamol
Origin:
EU

Panadol Extend (Paracetamol)

Paracetamol, the active ingredient in Panadol Extend, is an analgesic presented as a tablet for oral use. It treats mild to moderate pain and reduces fever in adults and children.

GNH India supplies Panadol Extend as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Haleon Netherlands B.V.

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Indications & Clinical Uses

Panadol Extend contains paracetamol, an analgesic that acts on the body's pain‑relief pathways.

  • Headache: provides relief from tension‑type and mild migraine headaches.
  • Fever: helps lower elevated body temperature associated with infections.
  • Musculoskeletal pain: eases aches from back strain, sprains and minor joint discomfort.
  • Dental pain: reduces discomfort following dental procedures or toothache.
  • Menstrual cramps: alleviates mild to moderate dysmenorrhoeic pain.

How It Works

  • Paracetamol works primarily by inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2 in the central nervous system, which reduces the synthesis of prostaglandins involved in pain signalling and temperature regulation. It also modulates serotonergic pathways that contribute to its antipyretic effect.

Side Effects

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: mild stomach upset may be experienced.
  • Rash: occasional skin redness or mild itching.
  • Elevated liver enzymes: transient increase detected in blood tests.

Serious or Rare Side Effects

  • Hepatotoxicity: risk of liver injury with excessive dosing.
  • Stevens‑Johnson syndrome: severe skin reaction requiring urgent care.
  • Anaphylaxis: rare allergic response with difficulty breathing.
  • Blood disorders: uncommon cases of thrombocytopenia or neutropenia.

Precautions & Warnings

When using Panadol Extend, consider the following safety measures:

  • Dose limits: adhere to maximum daily paracetamol intake to avoid liver damage.
  • Alcohol use: limit alcohol consumption as it may increase hepatic risk.
  • Liver disease: use with caution in patients with existing liver impairment.
  • Pregnancy and breastfeeding: consult healthcare professional before use.
  • Children: ensure appropriate formulation and dosing for pediatric patients.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Paracetamol may interact with several medicines; monitoring is advised.

Major Interactions (Avoid)

  • Warfarin: may enhance anticoagulant effect and increase bleeding risk.
  • Isoniazid: can raise risk of liver toxicity when combined.

Moderate Interactions (Monitor Closely)

  • Antiepileptics (e.g., carbamazepine, phenytoin): may reduce paracetamol plasma levels.
  • Rifampicin: may increase metabolism of paracetamol, lowering efficacy.
  • Oral contraceptives: may slightly increase hepatotoxic potential.
  • HIV protease inhibitors: may alter paracetamol clearance.

Frequently Asked Questions

Panadol Extend contains paracetamol and is used to relieve mild to moderate pain such as headaches, dental discomfort, musculoskeletal aches, and to reduce fever. It is suitable for adult patients and, when appropriately formulated, for children under medical supervision.

Paracetamol reduces pain and fever by inhibiting central cyclooxygenase enzymes, which lowers prostaglandin production in the brain. This action diminishes pain signalling and helps reset the hypothalamic temperature set‑point, providing antipyretic effects.

The specific dose of Panadol Extend is determined by the prescribing healthcare professional based on the patient’s age, weight, and clinical condition. Patients should follow the prescriber’s instructions and not exceed the recommended maximum daily amount of paracetamol.

Paracetamol is generally considered safe for short‑term use during pregnancy and lactation when prescribed by a healthcare provider. However, pregnant or nursing women should always consult their doctor before starting any medication, including Panadol Extend.

To order, submit an enquiry on the Panadol Extend product page at gnhindia.com, providing the required quantity and your institutional credentials. GNH India will verify your trade or procurement status, then respond with pricing, availability, shipping details and any necessary import documentation.

Panadol Extend offers prolonged paracetamol release, providing up to 8‑hour pain relief compared with immediate‑release paracetamol tablets that may require more frequent dosing. Unlike NSAIDs, it does not irritate the stomach lining or affect platelet function, making it a preferred option for patients with gastrointestinal sensitivities.

Store Panadol Extend tablets at temperatures below 25 °C in their original packaging. Keep the container tightly closed, protect it from moisture, humidity and direct sunlight to maintain product stability.

Panadol Extend is taken orally with a glass of water. The tablet should be swallowed whole and not crushed or chewed, ensuring the extended‑release matrix functions correctly for sustained drug delivery.

The most serious risk is hepatotoxicity, which can occur with overdose or when combined with other sources of paracetamol. Rare but severe reactions include Stevens‑Johnson syndrome and anaphylaxis. Patients should seek immediate medical attention if they notice signs of liver injury or severe allergic reactions.

Individuals with known hypersensitivity to paracetamol, severe liver disease, or those who have exceeded the maximum daily paracetamol dose should avoid Panadol Extend. It is also contraindicated in patients taking certain medications that markedly increase hepatotoxic risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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