Panadol Extra (Paracetamol, Caffeine)

Panadol Extra combines paracetamol and caffeine to address pain‑related pathways and enhance analgesic effectiveness.

• Headache: provides relief from tension‑type and mild migraine headaches.
• Fever: helps lower elevated body temperature associated with viral or bacterial infections.
• Muscular pain: eases soreness and discomfort from minor muscle strains or over‑exertion.
• Dental pain: reduces pain following dental procedures or toothache.
• Menstrual discomfort: lessens cramping and associated lower‑back pain.

• Paracetamol acts centrally by inhibiting cyclo‑oxygenase enzymes, reducing prostaglandin synthesis that mediates pain and fever. Caffeine blocks adenosine receptors, producing mild central nervous system stimulation that enhances the analgesic effect of paracetamol and can improve pain perception.

Paracetamol/caffeine tablets are generally well tolerated, but adverse reactions can occur.

Common Side Effects

• Nausea: mild stomach upset may be reported.
• Insomnia: caffeine can cause difficulty falling asleep.
• Restlessness: occasional feeling of jitteriness.
• Headache: paradoxical headache in rare cases.
• Gastro‑intestinal discomfort: mild abdominal pain or indigestion.

Serious or Rare Side Effects

• Allergic reaction: rash, itching, swelling, or difficulty breathing.
• Hepatotoxicity: liver injury with excessive dosing or pre‑existing liver disease.
• Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Anaphylaxis: rapid onset of life‑threatening allergic response.
• Blood disorders: unexplained bruising or bleeding.

When using Panadol Extra, consider the following safety measures:

• Dose limitation: do not exceed the maximum daily amount of paracetamol.
• Liver health: avoid use in patients with severe hepatic impairment.
• Caffeine sensitivity: caution in individuals prone to anxiety or insomnia.
• Drug interactions: review concomitant medications for potential additive effects.
• Pregnancy and lactation: consult a healthcare professional before use.
• Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Paracetamol and caffeine may interact with several medicines; monitoring is advised.

Major Interactions (Avoid)

• Warfarin: increased risk of bleeding due to altered metabolism.
• Carbamazepine: may reduce paracetamol effectiveness.
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