Panadol Extra (Paracetamol, Caffeine)

Panadol Extra combines paracetamol and caffeine to relieve pain and reduce fever through central analgesic pathways.

• Headache: provides rapid relief of tension‑type and mild migraine pain.
• Fever: lowers elevated body temperature in acute febrile episodes.
• Musculoskeletal pain: eases discomfort from backache, muscle strains and minor joint pain.
• Dental pain: alleviates pain following dental procedures or toothache.
• Menstrual discomfort: reduces cramping and associated low‑grade fever.

• Paracetamol acts primarily on central cyclooxygenase enzymes, reducing prostaglandin synthesis in the brain to lower pain perception and temperature set‑point. Caffeine blocks adenosine receptors, producing mild central nervous system stimulation that enhances the analgesic effect of paracetamol and can improve headache relief.

Paracetamol and caffeine are generally well tolerated, but adverse reactions can occur.

Common Side Effects

• Nausea: mild stomach upset may be reported.
• Insomnia: caffeine‑related difficulty falling asleep.
• Gastro‑intestinal discomfort: occasional stomach irritation.
• Headache: paradoxical headache in rare cases.
• Dizziness: transient light‑headedness.
• Rash: mild skin redness or itching.

Serious or Rare Side Effects

• Stevens‑Stevenson reaction: severe skin blistering and detachment.
• Anaphylaxis: acute, life‑threatening allergic reaction.
• Hepatotoxicity: liver injury with excessive dosing.
• Blood disorders: thrombocytopenia or neutropenia.
• Severe rash: toxic epidermal necrolysis.
• Cardiac arrhythmias: irregular heartbeat linked to high caffeine intake.

When using Panadol Extra, consider the following safety measures:

• Dose limitation: do not exceed the maximum daily amount of paracetamol.
• Liver health: avoid use in patients with severe hepatic impairment.
• Caffeine sensitivity: caution in individuals prone to insomnia or palpitations.
• Pregnancy and lactation: consult a healthcare professional before use.
• Drug interactions: review concomitant medications for potential conflicts.
• Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Panadol Extra may interact with several medication classes. Review 

Major Interactions (Avoid)

• Warfarin: may increase bleeding risk.
• Isoniazid: heightens risk of liver toxicity.
• High‑dose vitamin A: combined hepatotoxic .

Moderate 

Moderate Interactions (Monitor Closely)

• Antidepressants: may enhance serotonergic .
• Antiepileptic .

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