Product image of Panadol Night (Diphenhydramine Hydrochloride, Paracetamol) supplied by GNH India

Panadol Night

Active Ingredient:
Diphenhydramine Hydrochloride, Paracetamol
Origin:
EU

Panadol Night (Diphenhydramine Hydrochloride, Paracetamol)

Diphenhydramine Hydrochloride, the active ingredient in Panadol Night, is an antihistamine combined with an analgesic presented as a tablet for oral use. It relieves occasional nighttime pain and helps with sleep.

GNH India supplies Panadol Night as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Haleon Ireland Limited

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Indications & Clinical Uses

Panadol Night combines an analgesic and a sedating antihistamine to address pain that interferes with sleep. It is commonly used for:

  • Headache: reduces pain and promotes restfulness.
  • Minor musculoskeletal pain: eases aches and helps the user fall asleep.
  • Fever with discomfort: lowers temperature while providing nighttime relief.
  • Toothache: alleviates dental pain that disrupts sleep.
  • Menstrual cramps: lessens cramping pain and aids sleep onset.

How It Works

  • Paracetamol acts centrally to inhibit cyclooxygenase enzymes, reducing prostaglandin synthesis and lowering pain perception and fever. Diphenhydramine blocks H1 histamine receptors in the central nervous system, producing sedation and an anti‑itch effect, which together facilitate sleep while relieving pain.

Side Effects

Side effects may vary in frequency and severity.

Common Side Effects

  • Drowsiness: feeling unusually sleepy.
  • Dry mouth: reduced salivation.
  • Dizziness: light‑headed sensation.
  • Blurred vision: temporary focus issues.
  • Constipation: reduced bowel movements.
  • Nausea: mild stomach upset.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or breathing difficulty.
  • Liver injury: jaundice or dark urine.
  • Cardiac arrhythmia: irregular heartbeat.
  • Hallucinations or confusion: altered mental state.
  • Persistent vomiting: inability to keep fluids down.
  • Low blood pressure: dizziness on standing.

Precautions & Warnings

When using Panadol Night, consider the following safety measures:

  • Avoid alcohol: increases sedation and liver risk.
  • Do not operate machinery: drowsiness can impair coordination.
  • Monitor liver function: especially with chronic use or existing liver disease.
  • Use caution in the elderly: heightened sensitivity to sedative effects.
  • Pregnancy and breastfeeding: consult a healthcare professional before use.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Panadol Night may interact with several medicines. Review the following categories:

Major Interactions (Avoid)

  • Alcohol: amplifies central nervous system depression and liver toxicity.
  • Other CNS depressants: combined sedation may be excessive.
  • Hepatotoxic drugs: increased risk of liver injury.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: paracetamol can enhance anticoagulant effect.
  • Anticholinergic drugs: may worsen dry‑mouth and urinary retention.
  • MAO inhibitors: potential for heightened hypertensive response.

Frequently Asked Questions

Panadol Night is an over‑the‑counter combination of paracetamol and diphenhydramine designed to relieve occasional nighttime pain such as headache, muscle aches, or fever while helping the user fall asleep. It is intended for short‑term use when pain interferes with rest.

Diphenhydramine is an H1‑histamine receptor antagonist that crosses the blood‑brain barrier, producing sedation and reducing itching. In Panadol Night it adds a sleep‑promoting effect to the analgesic action of paracetamol, allowing pain relief and improved sleep quality.

The appropriate dose of Panadol Night is determined by a healthcare professional based on the individual’s age, weight, and medical condition. Users should follow the dosing instructions on the product label or those provided by their prescriber.

Pregnant or breastfeeding individuals should consult a healthcare provider before using Panadol Night. Paracetamol is generally considered low‑risk when used as directed, but diphenhydramine’s safety profile in pregnancy is less certain, so professional guidance is essential.

To order, submit an enquiry on the Panadol Night product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with single‑ingredient paracetamol tablets, Panadol Night adds diphenhydramine, offering both analgesia and sedation. This can be advantageous for patients who need pain relief and difficulty sleeping, whereas non‑sedating options lack the sleep‑inducing component.

Store Panadol Night below 25 °C in its original packaging, protecting it from moisture, heat and direct sunlight. Keep the container tightly closed and out of reach of children.

Panadol Night is taken orally with a glass of water, preferably shortly before bedtime. Swallow the tablet whole; do not crush or chew, unless the product label specifically permits it.

Serious risks include severe allergic reactions, liver injury from excessive paracetamol, and profound sedation leading to accidents or respiratory depression, especially when combined with other CNS depressants or alcohol.

Individuals with known hypersensitivity to paracetamol, diphenhydramine, or any excipients, as well as those with severe liver disease, uncontrolled asthma, or who are currently taking other strong sedatives, should avoid Panpanadol Night.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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