Panadol Nightpain (Diphenhydramine Hydrochloride, Paracetamol)

Panadol Nightpain contains diphenhydramine and paracetamol, which act on pain‑related pathways and histamine receptors to provide relief and promote sleep.

• Headache: Reduces pain intensity and helps the patient rest.
• Muscular aches and pains: Alleviates discomfort associated with muscle strain.
• Fever associated with pain: Lowers body temperature while easing pain.
• Minor arthritic pain: Provides analgesic effect for mild joint discomfort.
• Tension‑type headache: Relieves tension‑related head pain.

• Diphenhydramine blocks H1 histamine receptors in the central nervous system, producing sedation, while paracetamol inhibits cyclooxygenase enzymes, reducing prostaglandin synthesis to lower pain perception and fever. The combination offers both analgesic and sleep‑inducing effects.

Side effects may vary in frequency and severity.

Common Side Effects

• Drowsiness: Feeling unusually sleepy or fatigued.
• Dry mouth: Reduced salivation leading to a dry sensation.
• Dizziness: Light‑headed feeling, especially when standing quickly.
• Nausea: Mild stomach upset or queasiness.
• Blurred vision: Temporary visual disturbance.

Serious or Rare Side Effects

• Severe allergic reaction: Rash, itching, swelling, or difficulty breathing.
• Liver injury: Unexplained jaundice or dark urine.
• Cardiac arrhythmia: Irregular heartbeat.
• Hallucinations or confusion: Altered mental state.
• Persistent vomiting: Inability to retain fluids.

When using Panadol Nightpain, consider the following safety measures:

• Avoid alcohol: Increases sedation and liver load.
• Liver disease: Use only under medical supervision.
• Pregnancy and breastfeeding: Consult a healthcare professional before use.
• Elderly patients: Start with the lowest effective dose and monitor for confusion.
• Concomitant CNS depressants: May enhance drowsiness.
• Store below 25°C: Keep in the original packaging, protect from moisture and direct sunlight.

Panadol Nightpain can interact with several medicines. Review these categories:

Major Interactions (Avoid)

• Alcohol: Potentiates central nervous system depression and liver toxicity.
• Strong CYP450 inhibitors: May increase paracetamol levels, raising risk of hepatotoxicity.
• Monoamine oxidase inhibitors (MAOIs): Heightened anticholinergic effects.

Moderate Interactions (Monitor Closely)

• Other sedatives or antihistamines: Additive drowsiness.
• Warfarin: May enhance anticoagulant effect.
• Antiepileptic drugs: May alter paracetamol metabolism.