Product image of Panadol (Paracetamol) supplied by GNH India

Panadol

Active Ingredient:
Paracetamol
Origin:
EU

Panadol (Paracetamol)

Paracetamol, the active ingredient in Panadol, is an analgesic presented as a 500 mg tablet for oral use. It treats mild to moderate pain and reduces fever in adults and children.
GNH India supplies Panadol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Haleon Denmark Aps

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Indications & Clinical Uses

Panadol is an analgesic and antipyretic that works within the pain‑relief and fever‑reduction pathways.

  • Headache: provides relief from mild to moderate tension‑type headaches.
  • Fever: lowers body temperature in febrile episodes.
  • Musculoskeletal pain: eases aches of the back, muscles and joints.
  • Dental pain: reduces discomfort following dental procedures.
  • Common cold symptoms: helps control pain and fever associated with upper respiratory infections.

How It Works

  • Paracetamol acts centrally by inhibiting cyclo‑cyclooxygenase (COX) enzymes, particularly COX‑3, which reduces prostaglandin synthesis in the brain. This modulation lowers the hypothalamic set‑point for temperature and diminishes pain signalling pathways, providing analgesic and antipyretic effects without significant peripheral anti‑inflammatory activity.

Side Effects

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: occasional mild stomach upset.
  • Skin rash: transient redness or itching.
  • Elevated liver enzymes: mild, reversible changes in blood tests.

Serious or Rare Side Effects

  • Hepatotoxicity: risk of liver injury with overdose or chronic high‑dose use.
  • Stevens‑Johnson syndrome: rare severe skin reaction.
  • Anaphylaxis: extremely rare allergic response requiring immediate medical attention.
  • Blood disorders: rare cases of thrombocytopenia or neutropenia.

Precautions & Warnings

When using Panadol, consider the following safety measures.

  • Dose limitation: do not exceed the maximum daily amount recommended by a healthcare professional.
  • Liver health: avoid use in patients with severe hepatic impairment unless directed by a physician.
  • Alcohol use: limit alcohol consumption as it may increase liver toxicity risk.
  • Drug interactions: review concomitant medications for potential additive hepatotoxicity.
  • Pregnancy and breastfeeding: consult a healthcare provider before use.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Paracetamol may interact with several medicines; monitoring is advised.

Major Interactions (Avoid)

  • Warfarin: increased anticoagulant effect may raise bleeding risk.
  • High‑dose ibuprofen or other NSAIDs: combined hepatotoxic potential.

Moderate Interactions (Monitor Closely)

  • Antiepileptic drugs (e.g., carbamazepine, phenytoin): may reduce paracetamol plasma levels.
  • Rifampicin: may increase metabolism, lowering efficacy.
  • Alcohol: enhances risk of liver injury.
  • HIV protease inhibitors: may alter paracetamol clearance.

Frequently Asked Questions

Panadol contains paracetamol, an analgesic and antipyretic used to relieve mild to moderate pain such as headache, toothache, muscle aches, and to reduce fever associated with colds or infections. It is commonly taken by adults and children when a non‑prescription option for pain or fever control is needed.

Paracetamol works by inhibiting central cyclo‑oxygenase enzymes, especially COX‑3, which lowers prostagtablet of prostaglandins in the brain. This action reduces the hypothalamic set‑point for temperature and dampens pain‑signal transmission, providing relief without strong peripheral anti‑inflammatory effects.

The appropriate dose of Panadol is determined by a prescriber or according to the product label, taking into account the patient’s age, weight, and clinical condition. Patients should follow the recommended dosing instructions and not exceed the maximum daily amount without medical advice.

Paracetamol is generally considered compatible with pregnancy and lactation when used at the lowest effective dose for short periods. However, pregnant or nursing individuals should consult their healthcare provider before taking Panadol to confirm that it is appropriate for their specific situation.

To order Panadol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with non‑steroidal anti‑inflammatory drugs (NSAIDs) such as ibuprofen, Panadol provides analgesic and antipyretic effects without significant anti‑inflammatory activity or gastrointestinal irritation. It is often preferred when NSAIDs are contraindicated, but it lacks the anti‑inflammatory benefits of those agents.

Panadol tablets should be stored below 25 °C in a dry place, protected from moisture and direct sunlight. Keep the medication in its original packaging until use and ensure the container is tightly closed to maintain product stability.

Panadol is administered orally. Tablets are swallowed whole with water, and the formulation is designed for rapid absorption from the gastrointestinal tract to provide timely pain relief and fever reduction.

The most serious risk of Panadol is hepatotoxicity, which can occur with overdose or chronic high‑dose use, potentially leading to liver failure. Rare severe reactions include Stevens‑Johnson syndrome and anaphylaxis, which require immediate medical attention.

Individuals with known hypersensitivity to paracetamol, severe liver disease, or those taking other medications that may cause additive liver toxicity should avoid Panadol unless directed by a healthcare professional. Children under the recommended age for the specific tablet strength should also not use it.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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