Panadol Retard 8 Uur (Paracetamol)

Panadol Retard 8 Uur contains paracetamol, an analgesic‑antipyretic that works on the central pain‑relief pathway.

• Headache: provides sustained relief of tension‑type and mild migraine headache.
• Dental pain: reduces postoperative dental discomfort for up to eight hours.
• Musculoskeletal pain: alleviates back, joint and muscle aches with prolonged effect.
• Fever: lowers elevated body temperature in acute febrile states.
• Menstrual cramps: eases dysmenorrhoea with extended symptom control.

• Paracetamol exerts its effect primarily by inhibiting cyclo‑oxygenase enzymes in the central nervous system, which reduces prostaglandin synthesis. This action lowers the pain‑transmission threshold and modulates the hypothalamic heat‑regulation centre, providing analgesic and antipyretic effects without significant peripheral anti‑inflammatory activity.

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

• Nausea: mild stomach upset may be experienced.
• Rash: occasional skin redness or itching.
• Elevated liver enzymes: transient increase in laboratory values.
• Headache: paradoxical headache in a minority of users.

Serious or Rare Side Effects

• Hepatotoxicity: risk of liver injury with overdose or chronic high‑dose use.
• Stevens‑Johnson syndrome: rare severe skin reaction.
• Anaphylaxis: extremely rare allergic response.
• Blood disorders: rare cases of thrombocytopenia or neutropenia.

When using Panadol Retard 8 Uur, consider the following safety measures:

• Liver function monitoring: assess hepatic health in patients with chronic liver disease.
• Alcohol consumption: limit intake as alcohol can increase hepatotoxic risk.
• Concomitant paracetamol: avoid using other paracetamol‑containing products to prevent overdose.
• Pregnancy and lactation: use only if clearly indicated and prescribed by a healthcare professional.
• Storage: Store below 25°C: keep in the original pack, protect from moisture.

Paracetamol may interact with several medicines; awareness helps prevent adverse events.

Major Interactions (Avoid)

• Warfarin: may enhance anticoagulant effect and increase bleeding risk.
• Isoniazid: can potentiate liver toxicity when combined with paracetamol.

Moderate Interactions (Monitor Closely)

• Antiepileptics (e.g., carbamazepine, phenytoin): may increase paracetamol metabolism, reducing efficacy.
• Rifampicin: accelerates hepatic clearance, potentially lowering therapeutic effect.
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