Product image of Panadol Sinus Relief (Phenylephrine Hydrochloride, Paracetamol, Caffeine) supplied by GNH India

Panadol Sinus Relief

Active Ingredient:
Phenylephrine Hydrochloride, Paracetamol, Caffeine
Origin:
EU

Panadol Sinus Relief (Phenylephrine Hydrochloride, Paracetamol, Caffeine)

Phenylephrine Hydrochloride, the active ingredient in Panadol Sinus Relief, is a decongestant presented as a tablet for oral use. It relieves nasal congestion associated with colds, sinusitis and seasonal allergies. Paracetamol and caffeine are included to provide analgesic and stimulant effects, supporting symptom relief in adults.

GNH India supplies Panadol Sinus Relief as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Haleon Ireland Limited

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Indications & Clinical Uses

Panadol Sinus Relief combines three active ingredients that act on pain, inflammation and nasal congestion pathways.

  • Common cold: helps reduce headache, fever and sinus pressure associated with viral upper respiratory infections.
  • Sinusitis: alleviates sinus pain and pressure while improving nasal airflow.
  • Seasonal allergic rhinitis: eases nasal congestion and associated facial pain.

How It Works

  • Phenylephrine hydrochloride acts as an alpha‑adrenergic agonist, causing vasoconstriction of nasal mucosal blood vessels and reducing swelling. Paracetamol provides analgesic and antipyretic effects by inhibiting central cyclooxygenase enzymes, while caffeine enhances analgesia through adenosine‑receptor antagonism and increases central nervous system stimulation.

Side Effects

Side effects reported with Panadol Sinus Relief are generally mild and dose‑dependent.

Common Side Effects

  • Dry mouth: mild dryness of the oral cavity.
  • Insomnia: difficulty falling or staying asleep.
  • Nausea: mild stomach upset.
  • Tremor: slight shaking of hands or limbs.
  • Increased heart rate: mild palpitations.
  • Headache: transient head discomfort.

Serious or Rare Side Effects

  • Severe hypertension: marked rise in blood pressure.
  • Cardiac arrhythmia: irregular heart rhythm.
  • Allergic reaction: rash, itching, swelling or difficulty breathing.
  • Liver injury: elevated liver enzymes or jaundice.
  • Seizures: convulsive episodes, particularly in overdose.
  • Anaphylaxis: life‑threatening systemic allergic response.

Precautions & Warnings

When considering Panadol Sinus Relief, several safety points should be reviewed.

  • Cardiovascular disease: avoid if uncontrolled hypertension or recent heart attack.
  • Liver impairment: use with caution in patients with known hepatic dysfunction.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Drug interactions: review concomitant medications for potential additive effects.
  • Age restrictions: not recommended for children under 12 years without medical advice.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Panadol Sinus Relief may interact with several drug classes; monitoring is advised.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Anticoagulants (e.g., warfarin): increased bleeding risk from paracetamol.
  • Beta‑blockers: may blunt the decongestant effect of phenylephrine.

Moderate Interactions (Monitor Closely)

  • Other stimulants (e.g., pseudo‑ephedrine): additive cardiovascular stimulation.
  • CYP1A2 substrates (e.g., theophylline): caffeine may increase plasma levels.
  • Diuretics: enhanced risk of electrolyte imbalance.

Frequently Asked Questions

Panadol Sinus Relief is formulated to relieve nasal congestion, sinus pressure, headache and fever associated with common colds, sinusitis and seasonal allergic rhinitis. The combination of phenylephrine, paracetamol and caffeine targets swelling of nasal passages, pain and fever, providing multi‑symptom relief for adults.

Phenylephrine is an alpha‑adrenergic agonist that narrows blood vessels in the nasal mucosa, reducing swelling and opening the airway. This vasoconstriction decreases congestion, allowing easier breathing during upper‑respiratory infections or allergic episodes.

The specific dose and frequency are determined by the prescribing healthcare professional based on the patient’s age, weight and clinical condition. Patients should follow the prescriber’s instructions and never exceed the recommended amount.

Safety in pregnancy and lactation has not been fully established. Women who are pregnant, planning pregnancy or breastfeeding should consult their physician before using this product to weigh potential benefits against any risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑ingredient decongestants, Panadol Sinus Relief adds paracetamol for pain and fever relief and caffeine to enhance analgesia. This broader symptom coverage can reduce the need for multiple separate medications, though the safety profile must be considered for patients with cardiovascular or hepatic concerns.

Store the tablets at temperatures below 25 °C in their original container, protected from moisture and direct sunlight. Maintaining these conditions helps preserve potency and prevents degradation of the active ingredients.

Panadol Sinus Relief is taken orally with a glass of water. The tablet should be swallowed whole and not chewed or broken, unless the prescriber provides an alternative administration instruction.

Serious risks include severe hypertension, cardiac arrhythmia, allergic reactions such as anaphylaxis, and liver injury. Patients experiencing rapid heartbeat, high blood pressure, rash, swelling or jaundice should seek immediate medical attention.

Individuals with uncontrolled hypertension, known hypersensitivity to phenylephrine, paracetamol or caffeine, severe liver disease, or those taking MAO inhibitors should avoid this product unless directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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