Panadol Ultra Rapide

Active Ingredient:: Paracetamol, Caffeine, Codeine Phosphate Hemihydrate
Origin:: EU

Panadol Ultra Rapide (Paracetamol, Caffeine, Codeine Phosphate Hemihydrate)

International sale not permitted. Listed for the domestic market and B2B only.

Paracetamol, the active ingredient in Panadol Ultra Rapide, is an analgesic combination presented as a tablet for oral use. It treats mild to moderate pain and reduces fever in adults and children when appropriate. GNH India supplies Panadol Ultra Rapide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

GNH India supplies Panadol Ultra Rapide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Haleon Czech Republic S.R.O.

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Indications & Clinical Uses

Panadol Ultra Rapide combines analgesic and antipyretic activity to relieve pain and fever across several common conditions.

Headache: provides rapid relief of tension‑type and migraine‑associated pain.
Dental pain: reduces discomfort following dental procedures or toothache.
Musculoskeletal pain: eases aches from strains, sprains and low‑back tension.
Fever: lowers elevated body temperature in febrile states.
Cold and flu symptoms: alleviates headache and body aches that accompany viral upper‑respiratory infections.

How It Works

Paracetamol acts centrally to inhibit cyclo‑oxygenase enzymes, reducing prostaglandin synthesis that mediates pain and fever. Caffeine enhances analgesic potency by antagonising adenosine receptors and increasing central nervous system stimulation. Codeine phosphate hemihydrate is a weak μ‑opioid receptor agonist that modulates pain signalling in the brain and spinal cord, providing additional relief.

Side Effects

Paracetamol, caffeine and codeine together are generally well tolerated, but adverse reactions can occur.

Common Side Effects

Nausea: mild stomach upset may be experienced.
Drowsiness: a feeling of sleepiness or reduced alertness.
Constipation: reduced bowel movements, especially with regular use.
Dizziness: light‑headed sensation.
Dry mouth: reduced salivation.
Insomnia: difficulty falling or staying asleep.

Serious or Rare Side Effects

Respiratory depression: slowed breathing, particularly at higher opioid doses.
Hepatotoxicity: liver injury from excessive paracetamol exposure.
Allergic reactions: rash, itching, swelling or anaphylaxis.
Seizures: rare occurrence, often linked to overdose.
Severe constipation or bowel obstruction.
Dependence or withdrawal symptoms with prolonged codeine use.

Precautions & Warnings

When using Panadol Ultra Rapide, consider the following safety measures:

Dose limits: adhere to maximum daily paracetamol intake to avoid liver damage.
Alcohol use: limit alcohol consumption as it may increase hepatotoxic risk.
Pre‑existing liver disease: use only under medical supervision.
Respiratory conditions: caution in patients with asthma or chronic obstructive pulmonary disease.
Opioid sensitivity: monitor for signs of opioid‑related side effects.
Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Panadol Ultra Rapide may interact with several medicines; monitoring is advised.

Major Interactions (Avoid)

Warfarin: increased bleeding risk due to enhanced anticoagulant effect.
MAO inhibitors: heightened risk of serotonin syndrome.
Other opioid analgesics: additive respiratory depression.

Moderate Interactions (Monitor Closely)

Antiepileptic drugs (e.g., carbamazepine): may reduce codeine effectiveness.
CYP3A4 inhibitors (e.g., erythromycin): can increase codeine plasma levels.
CNS depressants (e.g., benzodiazepines): may amplify drowsiness.
Alcohol: raises hepatotoxic potential of paracetamol.
Diuretics: may affect fluid balance and kidney function.

Frequently Asked Questions

Panadol Ultra Rapide is an oral analgesic combination containing paracetamol, caffeine and codeine. It is used to relieve mild to moderate pain such as headache, dental pain, musculoskeletal aches and to reduce fever associated with common infections.

Paracetamol reduces pain and fever by inhibiting central cyclo‑oxygenase enzymes, which lowers prostaglandin production in the brain. This action diminishes the perception of pain and helps reset the body’s temperature set‑point.

The appropriate dose is determined by a qualified prescriber based on the patient’s age, weight, clinical condition and local regulatory guidance. Patients should follow the specific instructions provided by their healthcare professional.

Paracetamol is generally considered safe in pregnancy when used at recommended doses, but codeine crosses the placenta and may affect the newborn. Breastfeeding mothers should consult a healthcare professional before using this product.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Compared with paracetamol‑only products, the addition of caffeine and codeine provides stronger analgesia and faster onset of relief. Unlike non‑steroidal anti‑inflammatory drugs, it does not irritate the stomach lining but does carry opioid‑related risks.

Store tablets below 25°C in their original container, protected from moisture and direct sunlight. Keep out of reach of children and do not use after the expiry date printed on the pack.

Panadol Ultra

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 12 Oct 2026

Disclaimer

International sale not permitted. Listed for the domestic market and B2B only.

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