Product image of Pancuroniumbromid Inresa (Pancuronium Bromide) supplied by GNH India

Pancuroniumbromid Inresa

Active Ingredient:
Pancuronium Bromide
Origin:
EU

Pancuroniumbromid Inresa (Pancuronium Bromide)

Pancuronium bromide, the active ingredient in Pancuroniumbromid Inresa, is a neuromuscular blocking agent presented as a sterile injectable solution for intravenous use. It provides skeletal muscle relaxation to facilitate endotracheal intubation and to maintain muscle relaxation during surgery.

GNH India supplies Pancuroniumbromid Inresa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Inresa Arzneimittel Gmbh

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Indications & Clinical Uses

Pancuronium bromide is used as a neuromuscular blocking agent to produce skeletal muscle relaxation during specific medical procedures.

  • Facilitation of endotracheal intubation: provides rapid muscle relaxation to allow safe airway placement.
  • Muscle relaxation during surgery: maintains a relaxed surgical field for optimal operative conditions.
  • Adjunct in controlled ventilation: enables precise control of ventilation parameters during anesthesia.

How It Works

  • Pancuronium bromide acts as a competitive antagonist at nicotinic acetylcholine receptors located on the motor end‑plate of skeletal muscles. By blocking these receptors, it prevents acetylcholine‑mediated depolarization, thereby inhibiting neuromuscular transmission and producing a dose‑dependent skeletal muscle relaxation.

Side Effects

Adverse reactions may occur with the use of pancuronium bromide.

Common Side Effects

  • Hypotension: reduced blood pressure during administration.
  • Bradycardia: slower than normal heart rate.
  • Facial flushing: transient redness of the face.
  • Dry mouth: decreased salivation.
  • Nausea: feeling of sickness.
  • Vomiting: expulsion of gastric contents.

Serious or Rare Side Effects

  • Prolonged apnea: extended respiratory paralysis requiring ventilation.
  • Anaphylactic reaction: severe allergic response with potential airway compromise.
  • Hyperkalemia: elevated serum potassium levels.
  • Malignant hyperthermia trigger: rare but life‑threatening hypermetabolic state.
  • Cardiac arrhythmias: irregular heart rhythms.

Precautions & Warnings

When using pancuronium bromide, careful monitoring and specific precautions are essential.

  • Assess neuromuscular function: monitor depth of blockade with a peripheral nerve stimulator.
  • Avoid in patients with known hypersensitivity to pancuronium or related compounds.
  • Use with caution in cardiovascular disease: may cause tachycardia or hypertension.
  • Ensure adequate ventilation support: drug induces paralysis requiring mechanical ventilation.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Pancuronium bromide can interact with several other agents; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • Concurrent use with other non‑depolarizing neuromuscular blockers: additive paralysis.
  • Combination with aminoglycoside antibiotics: potentiates neuromuscular blockade.
  • Use with magnesium sulfate: enhances blockade.

Moderate Interactions (Monitor Closely)

  • Co‑administration with volatile anesthetics: may increase duration of action.
  • Interaction with cholinesterase inhibitors: may reduce effectiveness of pancuronium.
  • Concurrent use of calcium channel blockers: may modestly prolong neuromuscular effects.

Frequently Asked Questions

Pancuroniumbromid Inresa contains pancuronium bromide, a neuromuscular blocking agent used to produce skeletal muscle relaxation. It is primarily employed to facilitate endotracheal intubation and to maintain muscle relaxation throughout surgical procedures.

Pancuronium bromide competitively blocks nicotinic acetylcholine receptors at the motor end‑plate of skeletal muscles. By preventing acetylcholine from activating these receptors, it stops depolarization and interrupts neuromuscular transmission, resulting in a controlled, dose‑dependent muscle relaxation.

The appropriate dose is determined by the prescribing clinician based on the patient’s weight, clinical condition, and the intended procedure. Dosing regimens are individualized and should follow institutional protocols and the product’s prescribing information.

Safety data for pancuronium bromide in pregnancy and lactation are limited. It is generally classified as contraindicated unless the potential benefit justifies the potential risk to the fetus or infant. Clinicians should evaluate risks carefully before use in these populations.

Enquiries are submitted via the product page on gnhindia.com, where you specify the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Pancuronium bromide is a long‑acting, non‑depolarizing blocker with a relatively slow onset compared with agents such as rocuronium or vecuronium. Its prolonged duration can be advantageous for lengthy surgeries, but it may require careful monitoring of cardiovascular effects.

The product should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen. Vials should be kept in their original packaging until use to maintain sterility and potency.

Pancuroniumbromid Inresa is administered intravenously. It is supplied as a sterile injectable solution that is injected directly into a vein, usually as a bolus dose followed by titrated additional doses as required under continuous neuromuscular monitoring.

Serious risks include prolonged respiratory paralysis requiring mechanical ventilation, severe hypotension or tachycardia, anaphylactic reactions, and rare occurrences of malignant hyperthermia. Continuous monitoring of respiratory and cardiovascular status is essential during and after administration.

Patients with known hypersensitivity to pancuronium bromide or any component of the formulation should avoid its use. Caution is also advised in individuals with significant cardiovascular disease, severe hepatic or renal impairment, and in pregnant or lactating women unless benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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