Product image of Pandemic Influenza Vaccine H5n1 Astrazeneca (A/Vietnam/1203/2004 (H5n1) Strain (A/Vietnam/1203/2004, Medi 0141000136)) supplied by GNH India

Pandemic Influenza Vaccine H5n1 Astrazeneca

Active Ingredient:
A/Vietnam/1203/2004 (H5n1) Strain (A/Vietnam/1203/2004, Medi 0141000136)
Origin:
EU

Pandemic Influenza Vaccine H5n1 Astrazeneca (A/Vietnam/1203/2004 (H5n1) Strain (A/Vietnam/1203/2004, Medi 0141000136))

A/Vietnam/1203/2004 (H5N1) strain, the active ingredient in Pandemic Influenza Vaccine H5N1 Astrazeneca, is a vaccine presented as a nasal formulation for intranasal use. It is intended to prevent pandemic influenza caused by the H5N1 virus in at‑risk populations.

GNH India supplies Pandemic Influenza Vaccine H5N1 Astrazeneca as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with established cold‑chain logistics and regulatory support for global distribution. The company ensures product integrity through temperature‑controlled handling and provides documentation to meet import and health authority requirements.

Manufacturer / TM Owner

Astrazeneca Ab

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Indications & Clinical Uses

Pandemic Influenza Vaccine H5N1 Astrazeneca is used within the influenza vaccine family to provide prophylactic protection against H5N1 virus infection.

  • Pandemic influenza (H5N1): Provides immunity that reduces the risk of infection with the avian H5N1 influenza virus.
  • High‑risk populations (e.g., healthcare workers, travelers to endemic areas): Lowers the likelihood of acquiring H5N1 during exposure.
  • Outbreak response (regional or global H5N1 outbreaks): Supports rapid immunization campaigns to contain spread.
  • Public health emergency response: Enables authorities to vaccinate communities quickly during an H5N1 emergency.

How It Works

  • The vaccine contains the inactivated A/Vietnam/1203/2004 (H5N1) viral strain, which stimulates the immune system to produce specific antibodies against the hemagglutinin protein of H5N1. These antibodies recognize and neutralize the virus upon exposure, providing active immunity and reducing the severity or occurrence of infection.

Side Effects

Common Side Effects

  • Nasal irritation or mild congestion.
  • Low‑grade fever.
  • Headache.
  • Transient fatigue.

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reaction.
  • Guillain‑Barré syndrome.
  • Severe respiratory distress or bronchospasm.

Precautions & Warnings

Precautions should be observed before administration.

  • Pregnancy: Use only if potential benefits outweigh uncertain risks.
  • Breastfeeding: Consider possible exposure to infant; weigh benefits against unknown risks.
  • Immunocompromised individuals: Vaccine may elicit a reduced immune response.
  • Known hypersensitivity: Avoid if patient has a documented allergy to any vaccine component.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Potential interactions have been identified.

Major Interactions (Avoid)

  • Live attenuated vaccines: Concurrent use may diminish immune response to either product.
  • Immunoglobulin therapy: May neutralize vaccine antigen and reduce effectiveness.

Moderate Interactions (Monitor Closely)

  • Antipyretics (e.g., acetaminophen) taken prophylactically: May blunt antibody production.
  • Immunosuppressive drugs: Can lower vaccine‑induced immunity.
  • Co‑administration with other vaccines on the same day: Monitor for additive local or systemic reactions.

Frequently Asked Questions

Pandemic Influenza Vaccine H5N1 Astrazeneca is employed to prevent infection with the H5N1 avian influenza virus. It is indicated for individuals at high risk of exposure, such as healthcare personnel, travelers to endemic regions, and populations targeted during an H5N1 outbreak.

The A/Vietnam/1203/2004 strain is an inactivated viral antigen that triggers the immune system to generate antibodies against the H5N1 hemagglutinin protein. These antibodies recognize the virus on future exposure, neutralizing it and providing active immunity.

The specific dosing regimen, including the number of doses and interval between administrations, is determined by the prescribing healthcare professional based on regulatory guidance, patient age, health status, and the epidemiological context.

Safety data in pregnancy and lactation are limited. The vaccine should be administered to pregnant or breastfeeding women only when the potential benefits justify any uncertain risks, and after a risk‑benefit assessment by the treating clinician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping options and necessary import documentation.

This vaccine uses the A/Vietnam/1203/2004 strain delivered via the nasal route, whereas some alternatives are injectable and may use different H5N1 strains. Efficacy, safety profile, and administration method vary, so clinicians should consider strain match, delivery route, and local regulatory approvals when selecting a product.

The vaccine must be stored refrigerated at 2‑8 °C. It should be kept in its original packaging, protected from light, and must not be frozen or shaken. Maintaining the cold chain during transport and handling is essential to preserve potency.

Pandemic Influenza Vaccine H5N1 Astrazeneca is administered intranasally. The prescribed dose is sprayed into each nostril using the supplied delivery device, following aseptic technique and the prescriber's instructions.

Serious adverse events, although rare, include severe allergic reactions such as anaphylaxis, Guillain‑Barré syndrome, and significant respiratory distress. Patients should be observed for immediate hypersensitivity signs and instructed to seek medical attention promptly if severe symptoms develop.

Individuals with a known hypersensitivity to any component of the vaccine, including the viral strain or excipients, should not be vaccinated. Additionally, persons who have experienced a severe allergic reaction to a previous dose of an H5N1 vaccine should avoid further administration.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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