Product image of Pangrol (Pancreas Powder From Porcine) supplied by GNH India

Pangrol

Active Ingredient:
Pancreas Powder From Porcine
Origin:
EU

Pangrol (Pancreas Powder From Porcine)

Pancreas Powder From Porcine, the active ingredient in Pangrol, is a biological preparation presented as a powder for oral use. It provides digestive enzymes to support patients with exocrine pancreatic insufficiency and related conditions.
GNH India supplies Pangrol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Berlin-Chemie Ag

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Indications & Clinical Uses

Pangrol is used as a pancreatic enzyme replacement to aid digestion in conditions where endogenous pancreatic secretions are deficient.

  • Exocrine pancreatic insufficiency: supplies lipase, amylase and protease to improve nutrient absorption.
  • Chronic pancreatitis: provides supplemental enzymes to reduce malabsorption symptoms.
  • Cystic fibrosis: replaces missing pancreatic enzymes to support digestion and growth.

How It Works

  • Pancreas Powder From Porcine contains a mixture of lipase, amylase and protease enzymes that act in the intestinal lumen to hydrolyze dietary fats, carbohydrates and proteins. By supplementing the deficient endogenous pancreatic secretions, it restores normal digestive processes and enhances the breakdown and absorption of nutrients.

Side Effects

Pangrol may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal discomfort: mild pain or cramping after ingestion.
  • Flatulence: increased intestinal gas production.
  • Steatorrhea: oily stools due to incomplete fat digestion.
  • Nausea: feeling of queasiness.
  • Diarrhea: loose stools.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Allergic reaction (including anaphylaxis): signs of swelling, rash, difficulty breathing.
  • Pancreatitis exacerbation: severe abdominal pain with elevated enzymes.
  • Severe abdominal pain: persistent, intense pain not relieved by usual measures.
  • Hypersensitivity pneumonitis: rare respiratory symptoms.
  • Persistent vomiting: may lead to dehydration.

Precautions & Warnings

Before using Pangrol, consider the following safety measures.

  • Dose adjustment: evaluate renal or hepatic impairment and adjust dosage accordingly.
  • Allergy assessment: avoid if the patient has a known allergy to porcine proteins.
  • Monitoring: observe for gastrointestinal symptoms and adjust therapy if needed.
  • Pregnancy: use only when the potential benefit justifies the potential risk to the fetus.
  • Breastfeeding: weigh benefits against possible exposure to the infant.
  • Store at ambient temperature below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Pangrol may interact with other medications, requiring attention to avoid reduced efficacy or increased risk.

Major Interactions (Avoid)

  • Antacids (especially proton pump inhibitors): may diminish enzyme activity by raising gastric pH.
  • High‑fat meals exceeding enzyme capacity: can overwhelm supplementation and reduce effectiveness.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: altered absorption may affect hormone levels.
  • Broad‑spectrum antibiotics: changes in gut flora could influence enzyme activity.
  • Diabetes medications: improved digestion may affect blood glucose control, requiring monitoring.

Frequently Asked Questions

Pangrol is a porcine‑derived pancreatic enzyme powder used to replace deficient digestive enzymes in patients with exocrine pancreatic insufficiency, chronic pancreatitis, or cystic fibrosis. It helps improve the breakdown and absorption of fats, proteins, and carbohydrates, reducing symptoms such as steatorrhea, abdominal discomfort, and malnutrition.

The powder contains lipase, amylase and protease enzymes that act in the small intestine to hydrolyze dietary fats, carbohydrates and proteins. By providing these enzymes externally, it compensates for the lack of endogenous pancreatic secretions, restoring normal digestive processes and enhancing nutrient uptake.

The appropriate dose of Pangrol is individualized by the prescribing healthcare professional based on the patient’s age, weight, severity of enzyme deficiency, and dietary fat content. Dosage is typically expressed in lipase units per meal and adjusted according to clinical response and tolerance.

Limited clinical data are available for use in pregnancy and lactation. Pangrol should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers should discuss individual risk factors and monitor both mother and child closely.

To order Pangrol, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Pangrol is comparable to other porcine‑derived enzyme preparations in its composition of lipase, amylase and protease. Differences may lie in enzyme potency, particle size, and formulation (e.g., enteric coating). Clinicians choose a product based on patient tolerance, dosing convenience, and specific clinical needs.

Store Pangrol at ambient temperature below 25 °C in its original container, protecting it from moisture, heat and direct sunlight. Ensure the packaging remains sealed until use to maintain enzyme activity. Do not store in a refrigerator or freezer unless specifically instructed by the supplier.

Pangrol is taken orally, usually mixed with a small amount of water or soft food and consumed at the start of each main meal and snack that contains fat. The exact method (mixing vs. swallowing) should follow the prescribing clinician’s instructions to ensure optimal enzyme activation.

The most serious risks include allergic reactions that can progress to anaphylaxis, exacerbation of pancreatitis, and severe abdominal pain. Patients should seek immediate medical attention if they experience swelling, difficulty breathing, persistent severe pain, or any signs of a systemic allergic response.

Pangrol should not be used by individuals with a known hypersensitivity to porcine proteins or any of the product’s excipients. It is also contraindicated in patients with active pancreatitis until the condition is stabilized, and in those for whom enzyme replacement therapy is not indicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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