Product image of Pangrol (Pancreas Powder From Porcine) supplied by GNH India

Pangrol

Active Ingredient:
Pancreas Powder From Porcine
Origin:
EU

Pangrol (Pancreas Powder From Porcine)

Pancreas Powder, the active ingredient in Pangrol, is a digestive enzyme presented as a powder for oral use. It is employed to manage exocrine pancreatic insufficiency in adults and children with conditions that impair natural enzyme production.

GNH India supplies Pangrol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Berlin-Chemie Ag

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Indications & Clinical Uses

Pangrol provides pancreatic enzyme replacement for disorders that reduce digestive enzyme output.

  • Cystic Fibrosis: improves nutrient absorption and reduces steatorrhea.
  • Chronic Pancreatitis: alleviates maldigestion and supports weight maintenance.
  • Post‑Pancreatectomy: replaces lost enzymes after surgical removal of pancreatic tissue, aiding digestion.

How It Works

  • Pancreas Powder contains a mixture of lipase, amylase and protease enzymes derived from porcine pancreas. After oral administration, the enzymes survive gastric acidity and become active in the duodenum, where they hydrolyze dietary fats, carbohydrates and proteins, thereby compensating for the patient’s deficient endogenous pancreatic secretion and facilitating normal nutrient absorption.

Side Effects

Pangrol may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Abdominal discomfort: mild cramping or bloating after meals.
  • Flatulence: increased gas production.
  • Diarrhea: loose stools, especially with high‑fat meals.
  • Nausea: occasional feeling of queasiness.
  • Constipation: reduced bowel movements.
  • Oily or frothy stools: indicative of fat malabsorption.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Severe abdominal pain: may signal pancreatitis exacerbation.
  • Persistent vomiting: could indicate obstruction.
  • Hypersensitivity pneumonitis: rare respiratory symptoms.
  • Intestinal obstruction: blockage requiring medical attention.

Precautions & Warnings

Before initiating therapy with Pangrol, consider the following precautions.

  • Assess pancreatic function: confirm exocrine insufficiency diagnosis.
  • Monitor for allergic reactions: discontinue if signs of hypersensitivity appear.
  • Adjust dosage based on clinical response: titrate to achieve symptom control.
  • Use with meals and snacks: ensures enzymes act on ingested nutrients.
  • Avoid in known hypersensitivity to porcine proteins.
  • Store at ambient temperature: keep in original container, protect from moisture.

Avoid Interactions

Pangrol can interact with other medicines that affect its activity or absorption.

Major Interactions (Avoid)

  • Antacids (e.g., aluminum hydroxide): may neutralize enzyme activity.
  • Bile‑acid sequestrants (e.g., cholestyramine): bind enzymes and reduce efficacy.

Moderate Interactions (Monitor Closely)

  • Proton‑pump inhibitors: alter gastric pH, potentially affecting enzyme activation.
  • Antibiotics altering gut flora: may change digestion dynamics.
  • Warfarin: monitor INR as nutritional changes can affect anticoagulation.
  • Corticosteroids: may increase risk of gastrointestinal irritation.

Frequently Asked Questions

Pangrol is a pancreatic enzyme replacement product that supplies lipase, amylase and protease to patients with exocrine pancreatic insufficiency. It is indicated for conditions such as cystic fibrosis, chronic pancreatitis and after pancreatic surgery, where the body cannot produce sufficient digestive enzymes on its own.

Pancreas Powder contains a blend of digestive enzymes derived from porcine pancreas. After oral intake, the enzymes survive the acidic stomach environment and become active in the small intestine, where they break down fats, carbohydrates and proteins, compensating for the patient’s deficient endogenous enzyme production and improving nutrient absorption.

The dose of Pangrol is individualized. A qualified prescriber determines the amount based on the patient’s age, weight, severity of enzyme deficiency and dietary fat intake. The prescribing clinician will adjust the dose to achieve optimal control of maldigestion symptoms.

Safety data for Pangrol in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers should discuss the risks and benefits with the patient before initiating therapy.

To order Pangrol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and assistance with import documentation.

Pangrol provides a porcine‑derived enzyme blend similar to other pancreatic enzyme replacements such as Creon or Pancreaze. While the core enzymes are comparable, differences may exist in enzyme potency, particle size and formulation. Clinicians choose a product based on patient response, dosing convenience and individual tolerability.

Pangrol should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain enzyme stability throughout its shelf life.

Pangrol is taken orally, usually mixed with a small amount of water or soft food, and consumed at the start of each main meal and snack. This timing allows the enzymes to act on the ingested nutrients as they pass through the gastrointestinal tract.

The most serious risks include severe allergic reactions such as anaphylaxis, persistent abdominal pain that may indicate pancreatitis exacerbation, and rare cases of intestinal obstruction. Patients should seek immediate medical attention if they experience any signs of a serious reaction.

Pangrol is contraindicated in individuals with known hypersensitivity to porcine proteins or any of the product’s excipients. It should also be avoided in patients with active pancreatitis until the condition is stabilized, and in those who have experienced severe allergic reactions to pancreatic enzyme preparations.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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