Pangrol (Pancreas Powder From Porcine)

• Pangrol, containing pancreas powder from porcine, is used as an enzyme supplement for conditions involving exocrine pancreatic insufficiency.
• Exocrine pancreatic insufficiency: improves nutrient absorption by supplying digestive enzymes.
• Cystic fibrosis‑related pancreatic insufficiency: aids digestion of fats, proteins and carbohydrates.
• Chronic pancreatitis with enzyme deficiency: assists in fat digestion and reduces steatorrhea.

• Pancreas powder from porcine supplies a mixture of lipase, amylase and protease enzymes that act in the gastrointestinal tract. These enzymes hydrolyze dietary fats, carbohydrates and proteins, facilitating their breakdown and absorption. By supplementing deficient endogenous pancreatic secretions, the preparation helps restore normal digestive processes in patients with enzyme insufficiency.

Pancreas powder from porcine may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Abdominal discomfort or cramping.
• Flatulence or bloating.
• Diarrhea or loose stools.
• Nausea or mild vomiting.
• Constipation or oily stools.

Serious or Rare Side Effects

• Allergic reaction, including rash, itching or anaphylaxis.
• Severe abdominal pain indicating possible pancreatitis exacerbation.
• Intestinal obstruction or severe constipation.
• Persistent vomiting leading to dehydration.
• Unexplained weight loss or malnutrition despite therapy.

• When using Pangrol, certain precautions should be observed to ensure safety and effectiveness.
• Dose adjustment: consider individual severity of enzyme deficiency and nutritional status.
• Monitoring: watch for signs of allergic reaction, especially in patients with known porcine protein sensitivity.
• Contraindication: do not use in individuals with documented hypersensitivity to porcine-derived products.
• Pregnancy and lactation: only use if clearly needed and prescribed by a healthcare professional.
• Storage: Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Pancreas powder from porcine can interact with other medications or supplements, affecting its efficacy or safety.

Major Interactions (Avoid)

• Antacids containing aluminum or magnesium: may reduce enzyme activity.
• High‑dose proton pump inhibitors: may alter gastric pH and diminish enzyme effectiveness.

Moderate Interactions (Monitor Closely)

• Oral antibiotics: may affect gut flora, monitor digestive response.
• Fat‑soluble vitamin supplements: increased absorption may require level monitoring.
• Concurrent pancreatic enzyme products: additive effect may require dosage adjustment.