Pankreas-Pulver Vom Schwein (Pankreatin) Stada (Pancreas Powder From Porcine)

Pankreas-Pulver Vom Schwein (Pankreatin) Stada provides pancreatic enzymes for conditions characterized by exocrine pancreatic insufficiency.

• Exocrine pancreatic insufficiency: improves digestion of fats, proteins and carbohydrates by supplying the missing enzymes.
• Cystic fibrosis: aids nutrient absorption and reduces steatorrhea in patients with pancreatic dysfunction.
• Chronic pancreatitis: supports digestive processes when the pancreas cannot produce adequate enzymes.

• The porcine pancreatic powder contains a mixture of lipases, proteases and amylases that mimic endogenous pancreatic secretions. After oral administration, the enzymes act in the duodenum to hydrolyze dietary fats, proteins and carbohydrates, facilitating their absorption and reducing maldigestion associated with exocrine pancreatic insufficiency.

Adverse reactions may occur with any enzyme preparation. Patients should be aware of both common and less frequent events.

Common Side Effects

• Abdominal discomfort or cramping
• Flatulence or gas buildup
• Diarrhea or loose stools
• Nausea or mild vomiting
• Constipation
• Unpleasant taste or oral irritation

Serious or Rare Side Effects

• Allergic reactions such as urticaria, angioedema, or anaphylaxis
• Severe abdominal pain with vomiting
• Persistent or worsening gastrointestinal bleeding
• Respiratory distress or bronchospasm
• Serum eosinophilia or other hypersensitivity manifestations

Before initiating therapy, certain precautions should be considered to ensure safe use.

• Assess pancreatic enzyme requirement: determine dosage based on individual digestive needs.
• Monitor for allergic reactions: discontinue if signs of hypersensitivity appear.
• Use with meals: take the powder during or immediately after food to maximize enzyme activity.
• Adjust in renal impairment: evaluate dosing in patients with severe kidney disease.
• Avoid in known hypersensitivity to porcine proteins.
• Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Enzyme preparations can interact with other oral medications, affecting absorption or activity.

Major Interactions (Avoid)

• Antacids containing aluminum or magnesium: may bind enzymes and reduce efficacy.
• Cholestyramine or other bile acid sequestrants: can sequester enzymes, diminishing their therapeutic effect.

Moderate Interactions (Monitor Closely)

• Proton pump inhibitors: may alter gastric pH and affect enzyme activation; monitor clinical response.
• Warfarin: changes in vitamin K absorption could affect anticoagulation control; check INR regularly.
• Oral contraceptives: potential alteration in hormone absorption; observe for reduced contraceptive efficacy.