Panmigran (Paracetamol, Acetylsalicylic Acid, Caffeine)

Panmigran is a combination analgesic that acts on headache‑related pain pathways.

• Migraine: provides relief of moderate migraine attacks when taken at onset.
• Tension‑type headache: reduces pain intensity and improves functional ability.
• Mild to moderate pain: alleviates discomfort from musculoskeletal or dental sources.

• Panmigran combines paracetamol, acetylsalicylic acid and caffeine. Paracetamol inhibits central cyclo‑oxygenase enzymes, lowering prostaglandin‑mediated pain and fever. Aspirin irreversibly blocks COX‑1 and COX‑2, further decreasing prostaglandin synthesis. Caffeine antagonises adenosine receptors, enhancing central analgesic activity and improving drug absorption.

Adverse reactions may range from mild to serious and should be monitored during therapy.

Common Side Effects

• Nausea or upset stomach.
• Heartburn or dyspepsia.
• Headache that persists despite treatment.
• Dizziness or light‑headed feeling.
• Increased urinary frequency.

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration.
• Allergic reactions such as rash, itching or swelling.
• Severe liver injury, particularly with overdose.
• Asthma exacerbation triggered by aspirin sensitivity.
• Unexplained bruising or bleeding abnormalities.

Before using Panmigran, consider the following safety points:

• Assess risk of gastro‑intestinal bleeding: patients with a history of ulcers should use caution.
• Evaluate renal function: impaired kidneys may affect drug clearance.
• Review cardiovascular risk factors: aspirin can influence platelet function.
• Check allergy history: avoid if known hypersensitivity to any component.
• Store below 25°C: keep in the original packaging ​

• Panmigran may interact with several medication classes.
• Major Interactions (​​ ​):
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