Product image of Panmigrol Migraine And Headache Relief (Paracetamol, Acetylsalicylic Acid, Caffeine) supplied by GNH India

Panmigrol Migraine And Headache Relief

Active Ingredient:
Paracetamol, Acetylsalicylic Acid, Caffeine
Origin:
EU

Panmigrol Migraine And Headache Relief (Paracetamol, Acetylsalicylic Acid, Caffeine)

Paracetamol, Acetylsalicylic Acid and Caffeine, the active ingredients in Panmigrol Migraine And Headache Relief, are a combination analgesic presented as a tablet for oral use. It treats migraine and other types of headache in adults.

GNH India supplies Panmigrol Migraine And Headache Relief as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Haleon Uk Trading Limited

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Indications & Clinical Uses

  • Panmigrol Migraine And Headache Relief, a combination analgesic, is used for conditions involving vascular and neurogenic pain pathways.
  • Migraine: provides rapid relief of migraine attacks.
  • Headache: reduces intensity of common tension‑type headaches.
  • Tension‑type headache: alleviates pain associated with muscular tension and stress.

How It Works

  • Paracetamol inhibits central cyclooxygenase, lowering prostaglandin synthesis and reducing pain and fever. Acetylsalicylic acid irreversibly blocks COX‑1 and COX‑2 enzymes, decreasing peripheral prostaglandin production and providing anti‑inflammatory and antiplatelet effects. Caffeine antagonises adenosine receptors, enhancing the analgesic actions of the other two components and improving central pain perception.

Side Effects

Panmigrol Migraine And Headache Relief may cause a range of adverse reactions.

Common Side Effects

  • Nausea or upset stomach
  • Heartburn or indigestion
  • Dizziness or light‑headedness
  • Insomnia or restlessness
  • Mild headache
  • Increased urinary frequency

Serious or Rare Side Effects

  • Allergic reactions such as rash, angioedema, or anaphylaxis
  • Gastrointestinal bleeding or ulcer formation
  • Severe liver injury (rare, linked to paracetamol overdose)
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Hemorrhagic stroke in susceptible individuals

Precautions & Warnings

  • Before using Panmigrol Migraine And Headache Relief, consider the following safety measures.
  • Liver disease: avoid or use with caution in patients with hepatic impairment.
  • Gastrointestinal ulcer or bleeding: contraindicated in active ulcer disease.
  • Asthma or aspirin sensitivity: assess risk before administration.
  • Pregnancy and breastfeeding: safety not established; consult a healthcare professional.
  • Alcohol consumption: limit intake as it may increase liver toxicity.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Panmigrol Migraine And Headache Relief can interact with several medicines; awareness of the interaction level is essential.

Major Interactions (Avoid)

  • Warfarin or other anticoagulants: increased bleeding risk.
  • Other NSAIDs or aspirin-containing products: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs) or SNRIs: heightened hemorrhagic potential.
  • Alcohol: synergistic hepatotoxicity.
  • Lithium: caffeine may raise lithium serum levels.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: caffeine may reduce blood‑pressure‑lowering effect.
  • Diuretics: possible reduction in potassium levels.
  • Methotrexate: NSAID component may increase methotrexate toxicity.
  • Corticosteroids: combined GI irritation risk.
  • Oral hypoglycemics: caffeine may affect glucose control.

Frequently Asked Questions

Panmigrol Migraine And Headache Relief is an over‑the‑counter combination analgesic indicated for the relief of migraine attacks and other common headache types, such as tension‑type headaches, in adult patients.

Paracetamol reduces pain and fever by inhibiting central cyclooxygenase. Acetylsalicylic acid irreversibly blocks COX enzymes, decreasing prostaglandin synthesis and providing anti‑inflammatory and antiplatelet effects. Caffeine antagonises adenosine receptors, which enhances the analgesic potency of the other two agents and improves pain perception.

The appropriate dose is determined by the prescribing healthcare professional based on the individual’s condition, age, and other factors. Patients should follow the prescriber’s instructions and never exceed the recommended amount on the product label.

Safety in pregnancy and lactation has not been fully established. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their physician before using this product.

Enquiries can be submitted via the product page on gnhindia.com by providing the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then replies with pricing, availability, shipping details and any necessary import documentation.

Panmigrol combines a non‑opioid analgesic (paracetamol), an NSAID (acetylsalicylic acid) and caffeine, offering a rapid, multi‑mechanistic approach. Compared with single‑agent triptans, it may be less specific but provides a broader anti‑pain and anti‑inflammatory effect, suitable for mild to moderate attacks.

Store the tablets at ambient temperature, below 25 °C, in the original container. Keep them away from moisture, direct sunlight and out of reach of children.

The product is taken orally, usually with a full glass of water. It should be swallowed whole and not chewed or crushed unless directed by a healthcare professional.

Serious risks include allergic reactions (rash, angioedema, anaphylaxis), gastrointestinal bleeding or ulcer, and rare but severe liver injury if the paracetamol component is overdosed. Patients should seek immediate medical attention if they experience any of these symptoms.

Individuals with known hypersensitivity to paracetamol, aspirin, or caffeine, those with active peptic ulcer disease, bleeding disorders, severe liver disease, or children under 12 years (due to aspirin‑related risks) should not use this product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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