Product image of Panodil Extra (Paracetamol, Caffeine) supplied by GNH India

Panodil Extra

Active Ingredient:
Paracetamol, Caffeine
Origin:
EU

Panodil Extra (Paracetamol, Caffeine)

Paracetamol, the active ingredient in Panodil Extra, is an analgesic/antipyretic presented as a combination tablet for oral use. It treats mild to moderate pain and reduces fever in adults and children when appropriate.

GNH India supplies Panodil Extra as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Haleon Denmark Aps

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Indications & Clinical Uses

Panodil Extra combines paracetamol and caffeine to address pain‑related pathways and fever. It is commonly used for:

  • Headache: provides relief of tension‑type and migraine‑associated pain.
  • Dental pain: reduces discomfort after dental procedures.
  • Musculoskeletal pain: alleviates aches from strain, sprain or arthritis.
  • Fever: lowers elevated body temperature in acute infections.
  • Cold‑related discomfort: eases sinus pressure and headache associated with common colds.

How It Works

  • Paracetamol acts centrally by inhibiting cyclooxygenase enzymes, reducing prostaglandin synthesis that mediates pain and temperature regulation. Caffeine antagonises adenosine receptors, enhancing central nervous system stimulation and modestly increasing analgesic potency of paracetamol through pharmacodynamic synergy.

Side Effects

Adverse reactions may occur with any medication.

Common Side Effects

  • Nausea: mild stomach upset reported in some users.
  • Insomnia: difficulty sleeping due to caffeine content.
  • Gastric discomfort: mild abdominal pain or heartburn.
  • Headache: paradoxical headache in rare cases.
  • Rash: mild skin irritation or itching.

Serious or Rare Side Effects

  • Hepatotoxicity: risk of liver injury with excessive paracetamol intake.
  • Allergic reaction: hives, swelling, or anaphylaxis.
  • Blood disorders: rare cases of thrombocytopenia or neutropenia.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Cardiovascular effects: palpitations or arrhythmia linked to caffeine.

Precautions & Warnings

When using Panodil Extra, consider the following safety measures:

  • Dose limitation: avoid exceeding the maximum daily paracetamol amount.
  • Liver health: assess hepatic function in patients with liver disease.
  • Caffeine sensitivity: monitor individuals prone to anxiety, insomnia or tachycardia.
  • Pregnancy and lactation: use only if clearly indicated and prescribed.
  • Drug interactions: review concomitant medications for potential synergy.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Panodil Extra may interact with several medicines.

Major Interactions (Avoid)

  • Warfarin: increased bleeding risk due to altered metabolism.
  • Isoniazid: heightened hepatotoxic potential.
  • Highly active antiretroviral therapy: may affect paracetamol clearance.

Moderate Interactions (Monitor Closely)

  • Other CNS stimulants: additive effects on heart rate and anxiety.
  • Diuretics: potential for reduced plasma volume affecting drug concentration.
  • Oral contraceptives: may increase paracetamol plasma levels.
  • Antiepileptic drugs: enzyme induction may lower analgesic efficacy.

Frequently Asked Questions

Panodil Extra is a fixed‑dose combination of paracetamol and caffeine indicated for the short‑term relief of mild to moderate pain such as headache, dental or musculoskeletal pain, and for the reduction of fever associated with acute infections.

Paracetamol reduces pain and fever by centrally inhibiting cyclooxygenase enzymes, which lowers prostaglandin production involved in nociception and temperature control. The added caffeine blocks adenosine receptors, providing mild stimulation and enhancing the analgesic effect.

The prescribed dose of Panodil Extra is determined by the treating clinician based on the patient’s age, weight, pain severity and overall health status. The prescriber will specify the exact amount and frequency according to local guidelines.

Paracetamol is generally considered compatible with pregnancy when used at recommended doses, but caffeine exposure should be limited. Breastfeeding mothers should follow their healthcare provider’s advice, as small amounts may pass into milk. Use only if clearly indicated.

To request Panodil Extra, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Panodil Extra combines paracetamol with caffeine, which can increase analgesic potency and reduce perceived fatigue compared with paracetamol alone. The caffeine component may also cause mild stimulation, which some patients find beneficial for headache relief.

Store Panodil Extra tablets at temperatures below 25 °C, in the original container, protected from moisture and direct sunlight. Do not store in damp areas such as bathrooms or near heat sources.

Panodil Extra is taken orally with water. It may be taken with or without food, but patients who experience stomach upset can choose to take it with a light meal. Swallow tablets whole; do not crush or chew unless instructed by a healthcare professional.

The most serious risks include potential liver injury from excessive paracetamol intake and rare severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice signs of liver dysfunction or severe skin reactions.

Individuals with known hypersensitivity to paracetamol, caffeine or any excipients, patients with severe liver disease, and those who are pregnant or breastfeeding without medical justification should avoid Panodil Extra. Consultation with a healthcare professional is essential before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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