Product image of Panoral (Cefaclor Monohydrate) supplied by GNH India

Panoral

Active Ingredient:
Cefaclor Monohydrate
Origin:
EU

Panoral (Cefaclor Monohydrate)

Cefaclor, the active ingredient in Panoral, is a second‑generation cephalosporin presented as an oral tablet for systemic use. It treats a range of bacterial infections in adults and children, including sinusitis, otitis media, pneumonia, urinary tract and skin infections.

GNH India supplies Panoral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for export to EU and other markets. Customers benefit from reliable supply chains and responsive technical support.

Manufacturer / TM Owner

Dr. Friedrich Eberth Arzneimittel Gmbh

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Indications & Clinical Uses

  • Cefaclor is indicated for several bacterial infections affecting the respiratory, urinary and skin systems.
  • Acute bacterial sinusitis: eradicates sinus pathogens, relieving congestion and preventing complications.
  • Acute otitis media: targets common ear pathogens, reducing pain and inflammation.
  • Community‑acquired pneumonia: covers typical respiratory bacteria, supporting clinical recovery.
  • Uncomplicated urinary tract infections: eliminates uropathogens, relieving dysuria and preventing recurrence.
  • Skin and soft‑tissue infections: treats cellulitis and wound infections caused by susceptible organisms, promoting healing.

How It Works

  • Cefaclor inhibits bacterial cell‑wall synthesis by binding to penicillin‑binding proteins on the inner surface of the bacterial membrane. This blocks the transpeptidation step of peptidoglycan cross‑linking, weakening the cell wall and leading to osmotic lysis of susceptible Gram‑positive and some Gram‑negative organisms.

Side Effects

Cefaclor may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Diarrhea: loose stools, sometimes watery.
  • Vomiting: occasional emesis.
  • Abdominal pain: crampy discomfort.
  • Rash: mild skin erythema or pruritus.
  • Headache: transient tension‑type headache.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis): respiratory distress, hypotension, urticaria.
  • Clostridioides difficile‑associated colitis: severe diarrhea with abdominal pain.
  • Stevens‑Johnson syndrome/toxic epidermal necrolysis: extensive skin detachment and mucosal involvement.
  • Hemolytic anemia: sudden drop in hemoglobin with fatigue.
  • Liver enzyme elevation: hepatitis signs, jaundice.
  • Neutropenia: low white blood cell count, increased infection risk.

Precautions & Warnings

Before prescribing cefaclor, clinicians should consider several safety and handling factors.

  • Assess allergy history: avoid in patients with known cephalosporin or penicillin hypersensitivity.
  • Evaluate renal function: dose adjustment may be required in impaired clearance.
  • Monitor for superinfection: prolonged use can lead to fungal or bacterial overgrowth.
  • Caution in pregnancy: limited data; use only if benefit outweighs risk.
  • Use with caution in breastfeeding: small amounts excreted in milk, assess infant risk.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Cefaclor can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Probenecid: reduces renal excretion, increasing cefaclor plasma levels and toxicity risk.
  • Oral anticoagulants (warfarin): may enhance anticoagulant effect, increasing bleeding risk.

Moderate Interactions (Monitor Closely)

  • Metformin: reduced renal clearance may increase metformin levels; monitor for lactic acidosis.
  • Oral contraceptives: possible reduction in efficacy; advise additional contraceptive measures.
  • Diuretics (loop, thiazide): may affect renal function, requiring monitoring of cefaclor clearance.
  • Antacids containing aluminum or magnesium: may impair cefaclor absorption; separate dosing by at least 2 hours.

Frequently Asked Questions

Panoral, containing cefaclor, is prescribed for acute bacterial sinusitis, acute otitis media, community‑acquired pneumonia, uncomplicated urinary tract infections, and skin or soft‑tissue infections caused by susceptible bacteria.

Cefaclor binds to penicillin‑binding proteins on bacterial cell walls, inhibiting the transpeptidation step of peptidoglycan synthesis. This weakens the wall, causing osmotic lysis of susceptible Gram‑positive and some Gram‑negative organisms.

The exact dose of Panoral is set by the prescribing clinician based on the type and severity of infection, patient age, weight, renal function and local antimicrobial guidelines. No fixed regimen is provided here.

Safety data for cefaclor in pregnancy are limited, and the pregnancy category is listed as unknown. It should be used only if the potential benefit justifies any potential risk. Small amounts are excreted in breast milk; caution is advised.

Enquiries for Panoral can be submitted via the product page on gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Cefaclor is a second‑generation cephalosporin with broader activity against certain Gram‑negative organisms compared with amoxicillin, a penicillin derivative. However, amoxicillin may be preferred for some beta‑lactam‑sensitive infections, while cefaclor is useful when resistance to penicillins is suspected.

Panoral should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Keeping the product in a dry, cool environment helps maintain its potency throughout the shelf life.

Panoral is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless specifically directed by a healthcare professional. Dosing times and intervals are determined by the prescriber.

Serious risks include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, Stevens‑Johnson syndrome or toxic epidermal necrolysis, hemolytic anemia, and significant liver enzyme elevations. Patients should seek immediate medical attention if they experience symptoms like rash, difficulty breathing, persistent diarrhea or jaundice.

Panoral should be avoided in individuals with a known hypersensitivity to cefaclor, other cephalosporins, or penicillins. It is also contraindicated in patients with a history of severe allergic reactions to beta‑lactam antibiotics and in those with certain renal impairments without appropriate dose adjustment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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