Panoxyl Acnegel (Benzoyl Peroxide)

Panoxyl Acnegel is a topical keratolytic used in the management of acne‑related skin conditions.

• Acne vulgaris: helps reduce the number of inflammatory and non‑inflammatory lesions.
• Comedonal acne: promotes the clearance of blackheads and whiteheads.
• Mild to moderate papulopustular acne: assists in decreasing papule and pustule formation.

• Benzoyl peroxide releases free‑radical oxygen that oxidises bacterial proteins, killing Propionibacterium acnes while also promoting desquamation of follicular epithelium, which helps keep pores clear and reduces local inflammation.

Adverse reactions are generally limited to the application site and may vary in severity.

Common Side Effects

• Skin irritation: redness, itching, or burning at the site of application.
• Dryness: flaking or peeling of the treated skin.
• Mild erythema: temporary redness.
• Tingling sensation: transient feeling of pins and needles.
• Contact dermatitis: localized allergic response.

Serious or Rare Side Effects

• Severe allergic reaction: swelling, hives, or difficulty breathing.
• Extensive skin ulceration: deep sores or necrosis at the application site.
• Hyperpigmentation: persistent darkening of the skin.
• Widespread dermatitis: large‑area rash beyond the treated region.
• Systemic reactions: rare systemic hypersensitivity signs such as fever or malaise.

When using Panoxyl Acnegel, consider the following safety measures:

• Avoid excessive application: limit to the recommended thin layer.
• Test skin tolerance: perform a patch test on a small area before full use.
• Limit sun exposure: benzotoin may increase photosensitivity; use sunscreen.
• Discontinue if severe irritation occurs: stop use and seek medical advice.
• Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Benzoyl peroxide may interact with other topical agents and certain systemic medications.

Major Interactions (Avoid)

• Concurrent use with topical retinoids: may increase irritation.
• Combination with oral isotretinoin: heightened risk of severe skin dryness.

Moderate Interactions (Monitor Closely)

• Use with other keratin‑removing agents (e.g., salicylic acid): monitor for excessive dryness.
• Co‑administration with corticosteroid creams: may mask irritation signs.
• Interaction with dyes : the  ")