Product image of Pantadolor (Paracetamol) supplied by GNH India

Pantadolor

Active Ingredient:
Paracetamol
Origin:
EU

Pantadolor (Paracetamol)

Paracetamol, the active ingredient in Pantadolor, is an analgesic presented as a rectal formulation for OTC use. It treats mild to moderate pain and reduces fever in adults and children when appropriate.
GNH India supplies Pantadolor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Labialfarma - Laboratório De Produtos Farmacêuticos E Nutracêuticos, S.A.

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Indications & Clinical Uses

  • Pantadolor (paracetamol) acts on the central pain and temperature pathways to relieve discomfort and lower elevated body temperature.
  • Pain: provides relief of mild to moderate pain such as headache, muscular or dental pain.
  • Fever: reduces fever associated with infections or inflammatory conditions.
  • Headache: alleviates tension‑type headache and other common headache disorders.

How It Works

  • Paracetamol reduces pain and fever by inhibiting prostaglandin synthesis within the central nervous system, particularly in the hypothalamic heat‑regulation center. This action lowers the threshold for pain perception and resets the body's temperature set‑point, providing antipyretic and analgesic effects without significant peripheral anti‑inflammatory activity.

Side Effects

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: mild stomach upset may be experienced.
  • Abdominal discomfort: occasional stomach pain or discomfort.
  • Rash: skin redness or mild itching.
  • Dizziness: transient light‑headedness.
  • Elevated liver enzymes: mild, usually reversible changes.
  • Headache: occasional new or worsening headache.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reaction requiring immediate medical attention.
  • Hepatic failure: rare but potentially life‑threatening liver injury.
  • Anaphylaxis: acute allergic reaction with breathing difficulty.
  • Blood dyscrasias: rare cases of agranulocytosis or thrombocytopenia.
  • Severe skin reactions: toxic epidermal necrolysis.
  • Renal impairment: rare kidney function decline.

Precautions & Warnings

  • When using Pantodolor, consider the following safety measures.
  • Assess liver function: avoid use in patients with severe hepatic impairment.
  • Avoid exceeding recommended total daily dose: adhere to maximum limits to prevent toxicity.
  • Use with caution in alcohol users: concurrent alcohol may increase liver risk.
  • Consult healthcare professional before use in children: dosing must be age‑appropriate.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Paracetamol may interact with several medicines; monitoring is advised.

Major Interactions (Avoid)

  • Warfarin: increased anticoagulant effect may raise bleeding risk.
  • Carbamazepine: may reduce paracetamol efficacy by enhancing metabolism.
  • Isoniazid: combined use can heighten risk of liver toxicity.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may reduce contraceptive effectiveness.
  • Phenytoin: may alter paracetamol clearance.
  • Alcohol: concurrent use can exacerbate hepatotoxic potential.

Frequently Asked Questions

Pantadolor contains paracetamol and is used to relieve mild to moderate pain such as headache, muscular or dental discomfort, and to reduce fever associated with infections or inflammatory conditions. It is an over‑the‑counter option suitable for adults and, when appropriately dosed, for children.

Paracetamol works by inhibiting the synthesis of prostaglandins in the central nervous system, especially in the hypothalamus, which controls body temperature. This reduces the perception of pain and lowers the set‑point for fever, providing analgesic and antipyretic effects without significant peripheral anti‑inflammatory activity.

The appropriate dose of Pantadolor is determined by a qualified prescriber based on the patient’s age, weight, clinical condition, and overall health status. Healthcare professionals will calculate the exact amount and frequency to ensure safe and effective therapy.

Safety data for paracetamol in pregnancy and lactation are limited for this rectal formulation. Women who are pregnant, planning pregnancy, or breastfeeding should consult their healthcare provider before using Pantadolor to weigh potential benefits against any possible risks.

To order Pantadolor, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Both Pantadolor (paracetamol) and ibuprofen relieve pain and fever, but they act via different mechanisms. Paracetamol primarily works centrally with minimal anti‑inflammatory effect, while ibuprofen is a non‑steroidal anti‑inflammatory drug that also reduces inflammation. Choice depends on the clinical need, patient tolerance and any contraindications such as gastric or renal concerns.

Pantadolor should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Pantadolor is administered rectally. The appropriate suppository is inserted into the rectum, preferably after a bowel movement, and held in place for a few minutes to allow complete dissolution and absorption of the active ingredient.

The most serious risks include severe liver injury, especially when exceeding recommended doses or combining with alcohol, and rare allergic reactions such as Stevens‑Johnson syndrome or anaphylaxis. Patients should seek immediate medical attention if they notice signs of liver dysfunction, rash, or breathing difficulties.

Pantadolor should be avoided by individuals with known hypersensitivity to paracetamol, those with severe liver disease, and patients who have experienced serious skin reactions to similar drugs. Children under the age specified for the rectal formulation should also not use this product without medical guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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