Product image of Pantelmin (Mebendazole) supplied by GNH India

Pantelmin

Active Ingredient:
Mebendazole
Origin:
EU

Pantelmin (Mebendazole)

Mebendazole, the active ingredient in Pantelmin, is a benzimidazole anthelmintic presented as an oral tablet for oral use. It treats common intestinal worm infections such as ascariasis, hookworm, trichuriasis and enterobiasis in children and adults, providing effective parasite clearance across various geographic regions worldwide globally.

GNH India supplies Pantelmin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance. The company adheres to WHO GMP guidelines and provides reliable logistics for cross‑border distribution.

Manufacturer / TM Owner

Jntl Consumer Health (Portugal) Lda.

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Indications & Clinical Uses

Pantelmin (mebendazole) is used to treat intestinal helminth infections by disrupting parasite metabolism.

  • Ascariasis: eliminates Ascaris lumbricoides worms and reduces egg shedding.
  • Hookworm infection: eradicates Necator americanus and Ancylostoma duodenale, relieving anemia.
  • Trichuriasis: clears Trichuris trichiura infestations and improves gastrointestinal symptoms.
  • Enterobiasis: removes Enterobius vermicularis (pinworm) and prevents reinfestation.

How It Works

  • Mebendazole binds selectively to parasite β‑tubulin, inhibiting microtubule polymerisation. This impairs glucose uptake and other essential metabolic processes, leading to energy depletion and death of the helminth while sparing host cells.

Side Effects

Mebendazole is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Abdominal pain: mild to moderate discomfort in the stomach area.
  • Nausea: feeling of queasiness, sometimes leading to vomiting.
  • Diarrhoea: loose or watery stools.
  • Headache: mild to moderate head pain.
  • Dizziness: transient sense of light‑headedness.
  • Rash: mild skin irritation or itching.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or jaundice.
  • Severe allergic reaction: anaphylaxis, swelling of face or throat.
  • Neutropenia: marked reduction in white blood cells.
  • Stevens‑Johnson syndrome: severe skin blistering.
  • Bone marrow suppression: pancytopenia in rare cases.
  • Hepatic failure: rare but potentially life‑threatening liver dysfunction.

Precautions & Warnings

Before using Pantelmin, consider the following safety measures.

  • Pregnancy: unknown safety profile; avoid unless benefits outweigh risks.
  • Breastfeeding: assess risk; drug may be excreted in milk.
  • Liver disease: use with caution; monitor hepatic function.
  • Children: dosage must be determined by a qualified health professional.
  • Hypersensitivity: discontinue if allergic reactions develop.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture and light.

Avoid Interactions

Mebendazole may interact with other medicines; monitor accordingly.

Major Interactions (Avoid)

  • Cimetidine: may increase mebendazole plasma levels, risking toxicity.
  • Carbamazepine: induces metabolism, reducing efficacy.
  • Dexamethasone: may lower drug concentration, compromising treatment.
  • Antiretrovirals (e.g., ritonavir): can alter mebendazole metabolism.
  • Warfarin: potential enhancement of anticoagulant effect.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may reduce hormonal efficacy, consider backup contraception.
  • Other anthelmintics: concurrent use can increase adverse‑event risk.
  • Antacids: may affect absorption; separate administration by at least 2 hours.

Frequently Asked Questions

Pantelmin contains mebendazole, which is indicated for the treatment of common intestinal worm infections such as ascariasis, hookworm infection, trichuriasis and enterobiasis. It works by eliminating the adult parasites and reducing egg production in the gastrointestinal tract.

Mebendazole binds to the β‑tubulin of helminths, preventing microtubule formation. This blocks glucose uptake and other essential metabolic functions, leading to energy depletion and death of the parasite while having minimal effect on human cells.

The dosage of Pantelmin is determined by the prescribing clinician based on the specific infection, patient age, weight and local treatment guidelines. Patients should follow the exact regimen provided by their healthcare professional.

The safety of mebendazole in pregnancy has not been established, and it is classified as pregnancy category unknown. It should be used only if the potential benefit justifies the risk. Breastfeeding mothers should consult a physician, as the drug may be excreted in milk.

To order Pantelmin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Pantelmin (mebendazole) belongs to the benzimidazole class and offers broad‑spectrum activity against several intestinal nematodes. Compared with alternatives such as albendazole, mebendazole has a similar efficacy profile but may differ in absorption characteristics and drug‑interaction potential, making selection dependent on clinical context.

Pantelmin should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original packaging, protect them from moisture and direct light, and store them out of reach of children.

Pantelmin is taken orally, usually with a full glass of water. The tablet should be swallowed whole and not chewed or crushed unless directed by a healthcare professional. Follow the prescriber’s instructions regarding timing relative to meals.

Serious adverse events, although rare, can include hepatotoxicity, severe allergic reactions such as anaphylaxis, neutropenia, bone‑marrow suppression and Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience signs of liver dysfunction, severe rash, fever or unexplained bleeding.

Pantelmin should be avoided in individuals with known hypersensitivity to mebendazole or any benzimidazole compounds. Caution is advised for patients with severe liver disease, and it should not be used during pregnancy unless the potential benefit outweighs the risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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