Product image of Panthenol (Dexpanthenol) supplied by GNH India

Panthenol

Active Ingredient:
Dexpanthenol
Origin:
EU

Panthenol (Dexpanthenol)

Dexpanthenol, the active ingredient in Panthenol, is a Vitamin B5 derivative presented as an oral supplement for use in adults and children. It is classified as a provitamin that supports metabolic processes and contributes to the maintenance of healthy skin, mucous membranes, and wound healing. Panthenol is commonly employed where pantothenic acid deficiency is suspected or to aid tissue repair.

GNH India supplies Panthenol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Quintesence S.R.O.

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Indications & Clinical Uses

Panthenol is used to address conditions related to pantothenic acid deficiency and tissue repair.

  • Pantothenic acid deficiency: restores normal levels of vitamin B5 and alleviates associated symptoms such as fatigue and dermatitis.
  • Wound healing support: promotes epithelialization and accelerates the repair of skin lesions.
  • Skin and mucous membrane health: improves barrier function and reduces dryness in dermatological and oral mucosal conditions.

How It Works

  • After oral administration, dexpanthenol is rapidly absorbed and converted by cellular enzymes into pantothenic acid (vitamin B5). Pantothenic acid is a precursor of coenzyme A, which is essential for fatty acid synthesis, carbohydrate metabolism, and the production of acetyl‑CoA. By supporting coenzyme A formation, dexpanthenol facilitates energy production, protein synthesis, and the regeneration of skin and mucosal tissues, thereby aiding wound repair and maintaining barrier integrity.

Side Effects

Panthenol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Mild gastrointestinal discomfort: nausea, abdominal cramps.
  • Transient headache.
  • Skin irritation at sites of topical exposure (if applicable).
  • Allergic skin rash.
  • Increased sweating.

Serious or Rare Side Effects

  • Anaphylactic reaction: difficulty breathing, swelling of face or throat.
  • Severe hypersensitivity: urticaria, angioedema.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatic enzyme elevation in rare cases.
  • Hematologic abnormalities such as eosinophilia.

Precautions & Warnings

When considering Panthenol therapy, several safety measures should be observed.

  • Pregnancy: consult a healthcare professional before use, as safety data are limited.
  • Breastfeeding: discuss potential exposure with a physician.
  • Renal impairment: monitor for accumulation in severe kidney disease.
  • Known hypersensitivity: avoid if previous allergic reactions to dexpanthenol or related compounds occurred.
  • Drug interactions: review concomitant medications with a pharmacist.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Panthenol may interact with certain medications, requiring attention to dosage and monitoring.

Major Interactions (Avoid)

  • High‑dose sulfamethoxazole/trimethoprim: may reduce dexpanthenol absorption.
  • Anticonvulsants (e.g., phenytoin): potential decrease in vitamin B5 levels.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: possible alteration of vitamin metabolism.
  • Diuretics: may increase urinary loss of pantothenic acid.
  • Antibiotics (e.g., tetracyclines): could affect gut flora involved in vitamin synthesis.
  • Antacids containing aluminum or magnesium: may impair absorption if taken simultaneously.
  • Herbal supplements rich in vitamin B complex: monitor for additive effects.

Frequently Asked Questions

Panthenol, containing the active ingredient dexpanthenol, is used to correct pantothenic acid (vitamin B5) deficiency, support wound healing, and maintain healthy skin and mucous membranes. It is commonly prescribed for individuals with low vitamin B5 levels, for patients recovering from skin injuries, and for conditions that cause dryness or irritation of the skin and oral mucosa.

After oral intake, dexpanthenol is converted into pantothenic acid, which serves as a precursor for coenzyme A. Coenzyme A is vital for fatty acid synthesis, carbohydrate metabolism, and energy production. By enhancing coenzyme A availability, dexpanthenol supports cellular repair processes, promotes the regeneration of skin and mucosal tissues, and aids overall metabolic function.

The appropriate dose of Panthenol is determined by a qualified prescriber based on the individual’s age, clinical condition, and nutritional needs. Healthcare professionals consider factors such as the severity of deficiency, the presence of wounds, and any concurrent medications before recommending a specific dosage regimen.

Safety data for Panthenol in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before starting the supplement. The prescriber can assess whether the therapeutic advantages outweigh any uncertain safety considerations.

To place an order, visit the product page on gnhindia.com and submit an enquiry with the desired quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After receiving the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements), and assistance with import documentation.

Panthenol (dexpanthenol) is a provitamin that is converted in the body to active pantothenic acid, whereas some supplements provide pantothenic acid directly. Dexpanthenol may offer better absorption and tissue distribution, especially for supporting skin and wound repair, while direct pantothenic acid is often used for general nutritional supplementation.

Panthenol should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture, excessive heat, and direct sunlight. Ensure the packaging remains tightly closed to maintain product stability throughout its shelf life.

Panthenol is administered orally, typically in tablet, capsule, or liquid form as directed by a healthcare professional. The patient should follow the prescriber’s instructions regarding timing (e.g., with or without food) and any specific administration guidelines to optimize absorption.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, and toxic epidermal necrolysis. Patients should seek immediate medical attention if they experience symptoms like difficulty breathing, swelling of the face or throat, widespread rash, or blistering skin.

Individuals with a known hypersensitivity to dexpanthenol or any component of the formulation should avoid using Panthenol. Additionally, patients with severe renal impairment or those taking medications that may significantly interfere with vitamin B5 metabolism should consult a healthcare provider before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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