Product image of Pantium (Pantoprazole Sodium Sesquihydrate) supplied by GNH India

Pantium

Active Ingredient:
Pantoprazole Sodium Sesquihydrate
Origin:
EU

Pantium (Pantoprazole Sodium Sesquihydrate)

Pantoprazole, the active ingredient in Pantium, is a proton pump inhibitor presented as an oral tablet for oral use. It reduces gastric acid production and is indicated for conditions such as gastro‑oesophageal reflux disease, erosive esophagitis and peptic ulcer disease in adult patients.

GNH India supplies Pantium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Clonmel Healthcare Ltd.

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Indications & Clinical Uses

Pantium is a proton pump inhibitor used to manage acid‑related disorders of the upper gastrointestinal tract.

  • Gastro‑oesophageal reflux disease (GERD): alleviates heartburn and regurgitation by decreasing gastric acidity.
  • Erosive esophagitis: promotes healing of inflamed esophageal tissue caused by acid exposure.
  • Peptic ulcer disease: supports ulcer resolution and prevents recurrence through sustained acid suppression.

How It Works

  • Pantoprazole sodium sesquihydrate selectively binds to the H+/K+ ATPase enzyme (the gastric proton pump) on the secretory surface of parietal cells. By inhibiting this final step of acid secretion, it markedly reduces basal and stimulated gastric acid output, allowing mucosal healing and symptom relief in acid‑related gastrointestinal conditions.

Side Effects

Adverse reactions may occur with pantoprazole therapy.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhoea: loose stools occurring during treatment.
  • Nausea: occasional feeling of stomach upset.
  • Abdominal pain: mild discomfort in the upper abdomen.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Clostridioides difficile infection: persistent diarrhoea with abdominal cramping.
  • Low magnesium levels: muscle cramps, irregular heartbeat, or seizures in prolonged use.

Precautions & Warnings

Before initiating Pantium, consider the following safety measures.

  • Assess renal function: adjust use in patients with severe impairment.
  • Evaluate hepatic status: monitor in moderate liver disease.
  • Review concomitant medications: avoid drugs that require gastric acidity for absorption.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk, as safety data are limited.
  • Store at ambient temperature: keep below 25 °C, retain in the original container, and protect from moisture.

Avoid Interactions

Pantoprazole may alter the pharmacokinetics of several co‑administered agents.

Major Interactions (Avoid)

  • Ketoconazole or itraconazole: reduced antifungal absorption leading to therapeutic failure.
  • Atazanavir: markedly decreased antiviral exposure, compromising HIV treatment.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible increase in INR; monitor coagulation parameters.
  • Methotrexate (high dose): enhanced toxicity risk; consider dose adjustment or alternative therapy.

Frequently Asked Questions

Pantium contains pantoprazole, a proton pump inhibitor indicated for the management of gastro‑oesophageal reflux disease, erosive oesophagitis and peptic ulcer disease. By lowering stomach acid, it helps relieve symptoms such as heartburn and promotes healing of acid‑related lesions in the upper gastrointestinal tract.

Pantoprazole selectively inhibits the H+/K+ ATPase enzyme, commonly known as the gastric proton pump, located on the secretory surface of parietal cells. Blocking this final step of acid production decreases both basal and stimulated gastric acid secretion, providing sustained acid suppression and allowing mucosal recovery.

The appropriate dose of Pantium is determined by the prescribing healthcare professional based on the patient’s specific condition, severity, and response to therapy. Dosage regimens may vary, and patients should follow the prescriber’s instructions without altering the amount or frequency on their own.

Safety data for pantoprazole in pregnancy and lactation are limited. It should be used only when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers will evaluate individual circumstances before prescribing it to pregnant or nursing women.

To place an order, submit an enquiry on the Pantium product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details and any necessary import documentation.

Pantium (pantoprazole) belongs to the proton pump inhibitor class, which provides more potent and longer‑lasting acid suppression than H2‑receptor antagonists such as ranitidine. Compared with other PPIs, pantoprazole has a low potential for drug‑enzyme interactions, making it a suitable option for patients on multiple medications.

Pantium should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging to protect them from moisture and light. Do not store in areas with high humidity or extreme heat, and keep out of reach of children.

Pantium is taken orally, usually as a whole tablet with a glass of water. It can be taken with or without food, but consistency in relation to meals helps maintain stable absorption. Patients should swallow the tablet whole and not crush or chew it unless directed by a healthcare professional.

Serious adverse events, although rare, include severe allergic reactions (anaphylaxis, angioedema), Clostridioides difficile‑associated diarrhoea, and electrolyte disturbances such as hypomagnesemia, which can lead to muscle cramps, cardiac arrhythmias or seizures. Prompt medical attention is required if any of these symptoms occur.

Patients with known hypersensitivity to pantoprazole, other proton pump inhibitors, or any component of the formulation should avoid Pantium. Additionally, individuals with severe hepatic impairment or those taking medications that require an acidic environment for absorption should discuss alternatives with their prescriber.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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