Product image of Pantoprazol Hennig (Pantoprazole Sodium Sesquihydrate) supplied by GNH India

Pantoprazol Hennig

Active Ingredient:
Pantoprazole Sodium Sesquihydrate
Origin:
EU

Pantoprazol Hennig (Pantoprazole Sodium Sesquihydrate)

Pantoprazole Sodium Sesquihydrate, the active ingredient in Pantoprazol Hennig, is a proton pump inhibitor presented as a 40 mg tablet for oral use. It reduces stomach acid production and is used to treat acid‑related gastrointestinal conditions in adults and adolescents.

GNH India supplies Pantoprazol Hennig as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hennig Arzneimittel Gmbh & Co. Kg

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Indications & Clinical Uses

Pantoprazol Hennig is a proton pump inhibitor that acts on the gastric acid secretion pathway. It is indicated for several acid‑related disorders:

  • Gastro‑oesophageal reflux disease (GERD): provides relief of heartburn and promotes healing of erosive esophagitis.
  • Erosive gastritis and duodenal ulcer disease: supports ulcer healing by maintaining a low‑acid environment.
  • Zollinger‑Ellison syndrome: controls excessive gastric acid secretion associated with gastrin‑producing tumours.

How It Works

  • Pantoprazole selectively and irreversibly binds to the H+/K+‑ATPase enzyme (the gastric proton pump) on the secretory surface of parietal cells. By inhibiting this final step of acid production, it markedly lowers both basal and stimulated gastric acidity, allowing mucosal healing and symptom control.

Side Effects

Pantoprazol Hennig may cause adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhoea: loose stools without blood.
  • Nausea: occasional feeling of queasiness.
  • Abdominal pain: mild cramping.
  • Flatulence: increased intestinal gas.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis): rash, swelling, difficulty breathing.
  • Clostridioides difficile infection: persistent watery diarrhoea.
  • Low magnesium levels (hypomagnesemia): muscle cramps, irregular heartbeat.
  • Bone fractures: increased risk with long‑term use.
  • Liver enzyme elevation: abnormal liver function tests.
  • Acute interstitial nephritis: kidney inflammation presenting with fever and rash.

Precautions & Warnings

When prescribing Pantoprazol Hennig, clinicians should consider several safety aspects:

  • Renal impairment: dose adjustment may be required in severe kidney disease.
  • Hepatic impairment: monitor liver function in patients with liver disease.
  • Long‑term therapy: assess need for calcium and vitamin D supplementation to mitigate fracture risk.
  • Pregnancy and lactation: use only if clearly needed after risk‑benefit evaluation.
  • Drug interactions: review concomitant medications for potential CYP‑mediated effects.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Pantoprazol Hennig can affect the pharmacokinetics of several co‑administered drugs.

Major Interactions (Avoid)

  • Antifungal agents (ketoconazole, itraconazole): reduced absorption due to higher gastric pH.
  • HIV protease inhibitors (atazanavir, nelfinavir): decreased plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Clopidogrel: possible reduction in antiplatelet effect.
  • Warfarin: potential alteration of INR values.
  • Methotrexate (high dose): increased systemic exposure.
  • Digoxin: modest increase in serum levels.
  • Iron supplements: diminished absorption; separate dosing by at least 2 h.

Frequently Asked Questions

Pantoprazol Hennig contains pantoprazole, a proton pump inhibitor that is prescribed for acid‑related gastrointestinal disorders such as gastro‑oesophageal reflux disease, erosive gastritis, duodenal ulcers and Zollinger‑Ellison syndrome. It works by lowering stomach acid, which helps relieve symptoms and promotes healing of the gastrointestinal lining.

Pantoprazole blocks the H+/K+‑ATPase enzyme, also known as the gastric proton pump, on the surface of stomach parietal cells. By irreversibly inhibiting this final step of acid secretion, it reduces both basal and stimulated gastric acidity, creating a less aggressive environment for the mucosa and allowing ulcer healing.

The specific dose of Pantoprazol Hennig is determined by the prescribing clinician based on the patient’s condition, severity and response to therapy. Healthcare professionals set the appropriate strength, frequency and duration according to current clinical guidelines and individual patient needs.

Pantoprazol Hennig may be used during pregnancy or lactation only when the potential benefit outweighs any possible risk to the fetus or infant. Clinicians should evaluate each case individually and follow local regulatory guidance, as limited data are available for long‑term exposure in these populations.

To request Pantoprazol Hennig, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Pantoprazol Hennig is a proton pump inhibitor similar to omeprazole, esomeprazole and lansoprazole. All share the same mechanism of inhibiting the gastric proton pump, but differences exist in pharmacokinetic profiles, drug‑interaction potential and dosing convenience. Pantoprazole is often chosen for its lower propensity to interact with CYP‑mediated drugs.

Pantoprazol Hennig tablets should be stored at temperatures below 25 °C, in the original packaging, protected from moisture and direct sunlight. Maintaining these conditions helps preserve the tablet’s stability and potency throughout its shelf life.

Pantoprazol Hennig is taken orally, usually as a whole tablet with a glass of water. It can be taken with or without food, but consistent daily timing helps maintain steady acid suppression. Patients should follow the prescriber’s instructions regarding dose and duration.

Serious risks, though uncommon, include severe allergic reactions (anaphylaxis), Clostridioides difficile‑associated diarrhoea, low magnesium levels, bone fractures with long‑term use, liver enzyme elevations and acute interstitial nephritis. Patients should report any unusual symptoms promptly to their healthcare provider.

Pantoprazol Hennig is contraindicated in individuals with known hypersensitivity to pantoprazole or other proton pump inhibitors. Caution is also advised for patients with severe liver disease, those taking certain interacting medications, and anyone for whom acid suppression is not medically indicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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