Product image of Pantoprazol Holsten (Pantoprazole Sodium Sesquihydrate) supplied by GNH India

Pantoprazol Holsten

Active Ingredient:
Pantoprazole Sodium Sesquihydrate
Origin:
EU

Pantoprazol Holsten (Pantoprazole Sodium Sesquihydrate)

Pantoprazole Sodium Sesquihydrate, the active ingredient in Pantoprazol Holsten, is a proton pump inhibitor presented as a tablet for oral use. It reduces stomach acid production and is used to treat acid‑related disorders such as gastro‑oesophageal reflux disease and peptic ulcer disease in adults.

GNH India supplies Pantoprazol Holsten as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Macleods Pharma España, S.L.U

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Indications & Clinical Uses

Pantoprazol Holsten is a proton pump inhibitor that acts on the gastric acid secretion pathway. It is indicated for several acid‑related conditions:

  • Gastro‑oesophageal reflux disease (GERD): provides symptomatic relief and promotes healing of the oesophageal lining.
  • Erosive oesophagitis: accelerates mucosal healing and reduces further erosion.
  • Peptic ulcer disease: supports ulcer healing and helps prevent recurrence.
  • Zollinger‑Ellison syndrome: controls excessive gastric acid secretion associated with the condition.

How It Works

  • Pantoprazole selectively and irreversibly binds to the H+/K+‑ATPase enzyme (the gastric proton pump) on the secretory surface of parietal cells. By inhibiting this final step of acid production, it markedly lowers both basal and stimulated gastric acidity, allowing damaged mucosa to heal and reducing acid‑related symptoms.

Side Effects

Adverse reactions to pantoprazole may vary in frequency and severity.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhoea: usually self‑limiting.
  • Nausea: occasional and transient.
  • Abdominal pain: mild discomfort.
  • Flatulence: excess gas formation.
  • Constipation: infrequent bowel changes.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis): rash, swelling, breathing difficulty.
  • Clostridioides difficile infection: persistent watery diarrhoea.
  • Acute interstitial nephritis: kidney inflammation presenting with reduced urine output.
  • Low magnesium levels (hypomagnesemia): muscle cramps, irregular heartbeat.
  • Bone fractures: increased risk with long‑term use.
  • Liver enzyme elevation: abnormal liver function tests.

Precautions & Warnings

When prescribing Pantoprazol Holsten, consider the following safety measures:

  • Assess renal function: dose adjustment may be needed in severe impairment.
  • Review hepatic status: monitor if liver disease is present.
  • Evaluate need for long‑term therapy: prolonged use is linked to bone density loss.
  • Monitor electrolytes: especially magnesium during extended treatment.
  • Avoid abrupt discontinuation: taper to prevent rebound acid hypersecretion.
  • Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Pantoprazol Holsten can affect the pharmacokinetics of several co‑administered medicines.

Major Interactions (Avoid)

  • Ketoconazole or itraconazole: reduced antifungal absorption.
  • Atazanavir: markedly decreased antiviral exposure.
  • Clopidogrel: diminished antiplatelet effect.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential increase in INR, monitor coagulation.
  • Methotrexate: possible accumulation, check serum levels.
  • Digoxin: slight rise in serum concentration, observe for toxicity.

Frequently Asked Questions

Pantoprazol Holsten contains pantoprazole, a proton pump inhibitor that is prescribed for acid‑related disorders such as gastro‑oesophageal reflux disease, erosive oesophagitis, peptic ulcer disease and Zollinger‑Ellison syndrome. It works by lowering stomach acid, which helps relieve symptoms and promotes healing of the gastrointestinal lining.

Pantoprazole blocks the H+/K+‑ATPase enzyme, commonly called the gastric proton pump, located on the secretory surface of stomach parietal cells. By irreversibly inhibiting this pump, it stops the final step of acid secretion, leading to a sustained reduction in gastric acidity and allowing damaged tissue to recover.

The appropriate dose of Pantoprazol Holsten is determined by the prescribing clinician based on the specific indication, severity of disease, and patient characteristics. Healthcare professionals set the dosage regimen and duration according to current clinical guidelines and individual patient needs.

Pantoprazole is classified as pregnancy category B in many regions, indicating no evidence of risk in animal studies but limited human data. It should be used during pregnancy or lactation only if clearly needed and after a risk‑benefit assessment by the prescriber. Breastfeeding mothers should discuss potential exposure with their healthcare provider.

To place an order, submit an enquiry on the Pantoprazol Holsten product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Pantoprazol Holsten is comparable to other PPIs such as omeprazole, esomeprazole and lansoprazole in its ability to suppress gastric acid. Differences may include pharmacokinetic profiles, drug‑interaction potential and specific regulatory approvals. Clinicians choose a PPI based on individual patient response, interaction risk and formulary considerations.

Pantoprazol Holsten tablets should be stored at temperatures not exceeding 25 °C. Keep them in the original packaging to protect from moisture and light, and store them in a dry place away from direct heat or humidity to maintain product stability.

Pantoprazol Holsten is supplied as oral tablets that are taken with water. It is usually administered once daily, preferably in the morning before a meal, unless the prescriber advises a different schedule based on the patient’s condition.

Serious risks, though uncommon, include severe allergic reactions (anaphylaxis), Clostridioides difficile‑associated diarrhoea, acute interstitial nephritis, low magnesium levels, and increased risk of bone fractures with long‑term use. Patients should seek immediate medical attention if they experience symptoms such as rash, persistent diarrhoea, muscle cramps or unexplained fractures.

Pantoprazol Holsten is contraindicated in individuals with known hypersensitivity to pantoprazole or any other component of the formulation. Caution is also advised for patients with severe liver impairment, those taking certain interacting medications such as clopidogrel, and patients requiring long‑term therapy without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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