Product image of Pantoprazol Reig Jofre (Pantoprazole) supplied by GNH India

Pantoprazol Reig Jofre

Active Ingredient:
Pantoprazole
Origin:
EU

Pantoprazol Reig Jofre (Pantoprazole)

Pantoprazole, the active ingredient in Pantoprazol Reig Jofre, is a proton pump inhibitor presented as a tablet for oral use. It reduces stomach acid production and is used to treat conditions such as gastro‑oesophageal reflux disease and peptic ulcer disease in adults.

GNH India supplies Pantoprazol Reig Jofre as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratorio Reig Jofre, S.A.

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Indications & Clinical Uses

Pantoprazole is a proton‑pump inhibitor that acts on the gastric acid secretion pathway.

  • Gastro‑oesophageal reflux disease (GERD): Improves symptom control and promotes healing of the oesophageal lining.
  • Erosive esophagitis: Facilitates healing of erosions caused by acid exposure.
  • Peptic ulcer disease: Supports ulcer healing and reduces recurrence risk.

How It Works

  • Pantoprazole selectively inhibits the H+/K+‑ATPase enzyme (the gastric proton pump) located in the parietal cells of the stomach lining. By binding covalently to the pump’s cysteine residues, it blocks the final step of acid secretion, leading to a sustained increase in gastric pH and reduced acidity.

Side Effects

Pantoprazole is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache: mild and transient.
  • Diarrhea: usually self‑limiting.
  • Nausea: occasional mild upset.
  • Abdominal pain: mild cramping.
  • Flatulence: increased gas.
  • Constipation: occasional bowel change.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis): requires immediate medical attention.
  • Clostridioides difficile infection: may cause severe colitis.
  • Low magnesium levels (hypomagnesemia): can lead to muscle cramps or arrhythmia.
  • Bone fractures: long‑term use linked to reduced bone density.
  • Liver enzyme elevation: indicates possible hepatic stress.

Precautions & Warnings

Before initiating therapy, consider the following safety points:

  • Assess renal function: dose adjustment may be needed in severe impairment.
  • Review concomitant medications: potential for drug‑drug interactions.
  • Monitor for infection risk: prolonged acid suppression can increase gastrointestinal infection susceptibility.
  • Evaluate bone health: long‑term therapy may affect calcium absorption.
  • Pregnancy and lactation: use only if clearly needed after risk‑benefit assessment.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Pantoprazole may interact with several medicines; monitoring is recommended.

Major Interactions (Avoid)

  • Antifungal agents (ketoconazole, itraconazole): reduced absorption and efficacy.
  • HIV protease inhibitors (ritonavir, lopinavir): decreased plasma levels of the antiviral.
  • Clopidogrel: diminished antiplatelet effect, increasing cardiovascular risk.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible increase in INR; monitor coagulation parameters.
  • Methotrexate: reduced renal clearance may raise toxicity risk.
  • Digoxin: slight increase in serum concentrations; observe for toxicity signs.

Frequently Asked Questions

Pantoprazol Reig Jofre contains pantoprazole, a proton pump inhibitor indicated for the treatment of gastro‑oesophageal reflux disease, erosive esophagitis, and peptic ulcer disease. It works by lowering stomach acid, helping to relieve symptoms and promote healing of acid‑related gastrointestinal lesions.

Pantoprazole selectively blocks the H+/K+‑ATPase enzyme, also known as the gastric proton pump, in the stomach’s parietal cells. By inhibiting this final step of acid secretion, it raises gastric pH and reduces the amount of acid that contacts the lining of the stomach and oesophagus.

The dosage of Pantoprazol Reig Jofre is determined by the prescribing clinician based on the patient’s condition, severity, and response to therapy. The prescriber will set the appropriate strength, frequency and duration according to current clinical guidelines.

Pantoprazole is classified as pregnancy category B in many regions, indicating no evidence of risk in animal studies but limited human data. It should be used during pregnancy or lactation only if clearly needed after a careful risk‑benefit assessment by the healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Pantoprazole belongs to the proton pump inhibitor class, offering more potent and longer‑lasting acid suppression than H2‑receptor antagonists such as ranitidine. Compared with other PPIs, it has a similar efficacy profile but may have fewer drug‑interaction concerns with certain antiplatelet agents.

Store Pantoprazol Reig Jofre at temperatures below 25 °C in its original packaging. Protect the tablets from moisture, excessive heat and direct sunlight to maintain potency throughout its shelf life.

The product is supplied as oral tablets that are taken with water, usually before a meal. Patients should follow the prescribing clinician’s instructions regarding timing, whether the tablet should be swallowed whole or can be dispersed, and the length of therapy.

Serious adverse events, though uncommon, include severe allergic reactions (anaphylaxis), Clostridioides difficile‑associated colitis, low magnesium levels, and increased risk of bone fractures with long‑term use. Any signs of these conditions require immediate medical evaluation.

Pantoprazol Reig Jof should be avoided in patients with known hypersensitivity to pantoprazole or other proton pump inhibitors. Caution is also advised for individuals with severe liver disease, those taking clopidogrel, and patients who are pregnant or breastfeeding unless the benefit outweighs the risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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