Product image of Pantoprazol Viatris (Pantoprazole Sodium Sesquihydrate) supplied by GNH India

Pantoprazol Viatris

Active Ingredient:
Pantoprazole Sodium Sesquihydrate
Origin:
EU

Pantoprazol Viatris (Pantoprazole Sodium Sesquihydrate)

Pantoprazole, the active ingredient in Pantoprazol Viatris, is a proton pump inhibitor presented as an oral tablet for oral use in adult patients. It reduces gastric acid secretion and is employed to treat gastro‑esophageal reflux disease, erosive esophagitis, Zollinger‑Ellison syndrome, and to prevent NSAID‑induced gastric ulcers, and is commonly prescribed by gastroenterologists.

GNH India supplies Pantoprazol Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide and other healthcare institutions across multiple continents, ensuring reliable supply chains globally.

Manufacturer / TM Owner

Viatris Limited

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Indications & Clinical Uses

Pantoprazole is a proton pump inhibitor that acts on the gastric acid secretion pathway to manage acid‑related gastrointestinal disorders.

  • Gastro‑esophageal reflux disease (GERD): reduces reflux symptoms and promotes healing of esophageal irritation.
  • Erosive esophagitis: facilitates mucosal healing by decreasing gastric acid exposure.
  • Zollinger‑Ellison syndrome: controls excessive gastric acid production associated with gastrin‑secreting tumors.
  • Prevention of NSAID‑induced gastric ulcers: lowers ulcer risk in patients taking NSAIDs.

How It Works

  • Pantoprazole selectively and irreversibly binds to the H+/K+ ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells. By inhibiting this final step of acid production, it markedly reduces basal and stimulated gastric acid secretion, leading to an increase in gastric pH and allowing ulcerated tissue to heal.

Side Effects

Pantoprazole may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate pain in the head.
  • Diarrhea: loose stools occurring intermittently.
  • Nausea: feeling of sickness or urge to vomit.
  • Abdominal pain: discomfort or cramping in the stomach area.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis): swelling, difficulty breathing, rash.
  • Clostridioides difficile infection: severe diarrhea with abdominal pain.
  • Low magnesium levels (hypomagnesemia): muscle cramps, irregular heartbeat.

Precautions & Warnings

When prescribing Pantoprazol Viatris, clinicians should consider several safety aspects.

  • Assess renal function: adjust use in patients with severe renal impairment.
  • Evaluate liver disease: use cautiously in moderate to severe hepatic impairment.
  • Monitor long‑term use: prolonged therapy may increase risk of bone fractures.
  • Review concomitant medications: consider potential interactions with drugs requiring gastric pH for absorption.
  • Pregnancy and lactation: safety not established; prescribe only if benefit outweighs risk.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Pantoprazol Viatris can affect the pharmacokinetics of several co‑administered drugs.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect when co‑administered.
  • Atazanavir: decreased absorption of atazanavir leading to therapeutic failure.
  • Methotrexate (high dose): increased methotrexate toxicity due to reduced renal clearance.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible alteration of INR, monitor coagulation.
  • Digoxin: may increase serum digoxin levels, check levels.
  • Fluconazole: may increase pantoprazole exposure, monitor for side effects.

Frequently Asked Questions

Pantoprazol Viatris is indicated for the treatment of gastro‑esophageal reflux disease (GERD), erosive esophagitis, Zollinger‑Ellison syndrome, and for the prevention of gastric ulcers that can develop in patients taking non‑steroidal anti‑inflammatory drugs (NSAIDs).

Pantoprazole inhibits the H+/K+ ATPase enzyme, also known as the gastric proton pump, located on the secretory surface of parietal cells. This irreversible inhibition blocks the final step of acid production, leading to a marked decrease in gastric acid secretion and an increase in gastric pH.

The appropriate dose of Pantoprazol Viatris is determined by the prescribing healthcare professional based on the specific indication, severity of the condition, patient age, renal and hepatic function, and any concomitant therapies. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for pantoprazole in pregnancy and lactation are limited. It should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Pantoprazol Viatris, like other proton pump inhibitors, provides potent acid suppression. Compared with omeprazole, pantoprazole has a lower potential for CYP2C19‑mediated drug interactions and may be preferred in patients taking medications metabolized by this pathway. Clinical efficacy in healing ulcers and controlling reflux is comparable.

Pantoprazol Viatris should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Pantoprazol Viatris is taken orally as a tablet. The tablet should be swallowed whole with a glass of water, and it may be taken with or without food. Patients should follow the dosing schedule prescribed by their healthcare professional.

Serious risks, although rare, include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated diarrhea, and low magnesium levels (hypomagnesemia) that can cause muscle cramps or cardiac arrhythmias. Patients should seek immediate medical attention if they experience any of these symptoms.

Individuals with a known hypersensitivity to pantoprazole or any component of the formulation should avoid the product. Caution is also advised for patients with severe liver disease, and it should be used only under medical supervision in those with significant renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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