Product image of Pantoprazolo Aurobindo (Pantoprazole) supplied by GNH India

Pantoprazolo Aurobindo

Active Ingredient:
Pantoprazole
Origin:
EU

Pantoprazolo Aurobindo (Pantoprazole)

Pantoprazole, the active ingredient in Pantoprazolo Aurobindo, is a proton pump inhibitor presented as a tablet for oral use. It reduces gastric acid secretion and is used to treat conditions such as gastro‑oesophageal reflux disease and peptic ulcer disease in adults.

GNH India supplies Pantoprazolo Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo Pharma (Italia) S.R.L.

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Indications & Clinical Uses

Pantoprazolo Aurobindo, a proton pump inhibitor, is indicated for acid‑related gastrointestinal disorders.

  • Gastro‑oesophageal reflux disease (GERD): alleviates heartburn and esophageal irritation.
  • Peptic ulcer disease: promotes healing of gastric and duodenal ulcers.
  • Erosive oesophagitis: heals inflammation caused by acid exposure.
  • Zollinger‑Ellison syndrome: controls excessive gastric acid production.

How It Works

  • Pantoprazole selectively and irreversibly binds to the H+/K+‑ATPase enzyme (the gastric proton pump) on the secretory surface of parietal cells. By inhibiting this final step of acid secretion, it markedly reduces gastric acidity, allowing ulcer healing and relief of reflux symptoms. The effect persists for up to 24 hours after a single dose.

Side Effects

Pantoprazolo Aurobindo may cause a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate pain often resolving without treatment.
  • Diarrhoea: loose stools that may be self‑limiting.
  • Nausea: feeling of unease or upset stomach.
  • Abdominal pain: discomfort in the stomach region.
  • Flatulence: excess gas causing bloating.
  • Constipation: difficulty passing stools.

Serious or Rare Side Effects

  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Clostridioides difficile infection: severe colitis with watery diarrhoea.
  • Hypomagnesemia: low magnesium levels leading to muscle cramps or arrhythmia.
  • Liver enzyme elevation: signs of hepatic stress.
  • Stevens‑Johnson syndrome: life‑threatening skin reaction.
  • Interstitial nephritis: kidney inflammation presenting with reduced urine output.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Renal function assessment: adjust use in severe kidney disease.
  • Magnesium monitoring: check levels during prolonged treatment.
  • Hepatic impairment: use with caution in patients with liver disease.
  • Rebound acid hypersecretion: avoid abrupt discontinuation after long‑term use.
  • Drug interaction review: evaluate concomitant medications for potential conflicts.
  • Store at room temperature below 25°C: keep in the original packaging, protect from moisture.

Avoid Interactions

Pantoprazolo Aurobindo can interact with several medicines.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect, increasing clot risk.
  • Atazanavir: decreased absorption, lowering antiviral efficacy.
  • High‑dose methotrexate: increased toxicity due to reduced clearance.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible alteration of INR, requiring closer monitoring.
  • Diazepam: elevated plasma levels, enhancing sedation.
  • Digoxin: altered absorption, may affect cardiac monitoring.

Frequently Asked Questions

Pantoprazolo Aurobindo contains pantoprazole, a proton pump inhibitor that reduces stomach acid production. It is prescribed to manage conditions such as gastro‑oesophageal reflux disease, peptic ulcer disease, erosive oesophagitis, and Zollinger‑Ellison syndrome, helping to heal ulcers and relieve acid‑related symptoms.

Pantoprazole works by binding irreversibly to the H+/K+‑ATPase enzyme, also known as the gastric proton pump, on the secretory surface of parietal cells. This inhibition blocks the final step of acid secretion, leading to a sustained reduction in gastric acidity and allowing damaged tissues to heal.

The appropriate dose of Pantoprazolo Aurobindo is determined by the prescribing healthcare professional based on the specific indication, patient characteristics, and clinical response. Dosage instructions are provided on the prescription label and should be followed exactly as directed.

Pantoprazolo Aurobindo should only be used during pregnancy or while breastfeeding if the potential benefits outweigh any possible risks. Healthcare providers evaluate each case individually, considering the severity of the mother's condition and available safety data before prescribing.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will respond with pricing, availability, shipping details, and any required import documentation.

Pantoprazolo Aurobindo is comparable to other proton pump inhibitors such as omeprazole, esomeprazole, and lansoprazole in its ability to suppress gastric acid. Differences may lie in pharmacokinetic profiles, drug‑interaction potential, and specific regulatory approvals, but clinical efficacy for approved indications is generally similar across the class.

Pantoprazolo Aurobindo tablets should be stored at room temperature below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Pantoprazolo Aurobindo is taken orally, usually as a whole tablet with a glass of water. It is commonly recommended to take the dose before a meal, often in the morning, but the exact timing should follow the prescribing clinician’s instructions.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, low magnesium levels that can cause muscle cramps or cardiac arrhythmias, and liver enzyme elevations. Patients should seek immediate medical attention if they experience symptoms like rash, persistent diarrhea, or unexplained muscle weakness.

Pantoprazolo Aurobindo is contraindicated in patients with known hypersensitivity to pantoprazole or any component of the formulation. Caution is advised for individuals with severe liver disease, those taking medications that may interact significantly, and patients with a history of allergic reactions to proton pump inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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