Product image of Pantozol I.V. (Pantoprazole) supplied by GNH India

Pantozol I.V.

Active Ingredient:
Pantoprazole
Origin:
EU

Pantozol I.V. (Pantoprazole)

Pantoprazole, the active ingredient in Pantozol I.V., is a proton pump inhibitor presented as an injectable solution for intravenous use. It reduces gastric acid secretion and is used to treat conditions such as GERD, erosive esophagitis, and Zollinger‑Ellison syndrome in hospital settings.

GNH India supplies Pantozol I.V. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Manufacturer / TM Owner

Takeda Nederland B.V.

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Indications & Clinical Uses

Pantozol I.V. is indicated for acid‑related disorders that involve excessive gastric acid secretion.

  • Gastroesophageal reflux disease (GERD): provides rapid reduction of acid exposure to promote symptom relief.
  • Erosive esophagitis: facilitates healing of acid‑induced esophageal lesions.
  • Zollinger‑Ellison syndrome: controls acid hypersecretion associated with gastrin‑producing tumors.
  • Prevention of NSAID‑induced gastric ulcers: reduces risk of ulcer formation in patients receiving non‑steroidal anti‑inflammatory drugs.

How It Works

  • Pantoprazole irreversibly binds to the H+/K+ ATPase enzyme (gastric proton pump) on the secretory surface of parietal cells, blocking the final step of acid production. This inhibition markedly lowers gastric acidity, allowing the gastrointestinal mucosa to heal and reducing reflux‑related symptoms.

Side Effects

Adverse reactions to intravenous pantoprazole are generally mild to moderate and vary with individual sensitivity.

Common Side Effects

  • Headache: mild, transient headache reported in some patients.
  • Diarrhea: loose stools occurring during treatment.
  • Nausea: occasional feeling of queasiness.
  • Abdominal pain: mild discomfort in the stomach region.
  • Flatulence: increased intestinal gas.
  • Injection site reactions: mild redness or irritation at the infusion site.

Serious or Rare Side Effects

  • Severe hypersensitivity: rash, itching, swelling, or anaphylaxis.
  • Clostridioides difficile infection: severe colitis presenting with watery diarrhea.
  • Electrolyte disturbances: low magnesium or potassium levels.
  • Liver enzyme elevation: increased ALT or AST indicating hepatic stress.
  • Acute interstitial nephritis: kidney inflammation presenting with reduced urine output.
  • Thromboembolic events: rare blood clot formation.

Precautions & Warnings

Before administering Pantozol I.V., consider patient‑specific factors and monitoring requirements.

  • Pregnancy: Category B – use only if clearly needed.
  • Renal impairment: dose adjustment may be required in severe kidney dysfunction.
  • Hepatic impairment: monitor liver function tests in patients with liver disease.
  • Concomitant medications: review for drugs that may affect gastric pH or interact with pantoprazole.
  • Allergic history: assess for prior hypersensitivity to PPIs.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Pantoprazole can affect the absorption or metabolism of several co‑administered medicines.

Major Interactions (Avoid)

  • Ketoconazole or itraconazole: reduced antifungal absorption due to higher gastric pH.
  • Atazanavir: decreased antiviral efficacy from impaired dissolution.
  • Clopidogrel: diminished antiplatelet effect increasing cardiovascular risk.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible alteration of INR values; monitor coagulation.
  • Digoxin: increased serum levels; check therapeutic range.
  • Methotrexate: reduced renal clearance may raise toxicity risk.

Frequently Asked Questions

Pantozol I.V. is an intravenous formulation of pantoprazole used to treat acid‑related conditions such as gastro‑esophageal reflux disease, erosive esophagitis, Zollinger‑Ellison syndrome, and to help prevent gastric ulcers in patients receiving NSAIDs.

Pantoprazole irreversibly inhibits the gastric H+/K+ ATPase (proton pump) in parietal cells, blocking the final step of acid secretion. This results in a sustained reduction of stomach acidity, allowing damaged tissue to heal and reducing reflux symptoms.

The specific dose and infusion rate are determined by the prescribing clinician based on the patient’s condition, severity, and renal or hepatic function. Healthcare professionals set the appropriate regimen for each individual case.

Pantoprazole is classified as Pregnancy Category B, indicating no evidence of risk in animal studies but limited human data. It may be used during pregnancy only if clearly needed, and breastfeeding mothers should consult their physician before use.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Pantozol I.V. provides rapid, controlled acid suppression via intravenous delivery, which can be advantageous over oral proton pump inhibitors when oral intake is not possible or rapid effect is required. Compared with H2‑blockers, it offers more potent and longer‑lasting acid control.

Store the vials at 2‑8°C, protected from light. Do not freeze or shake the solution. Keep the product in its original packaging until use to maintain stability.

Pantozol I.V. is given by slow intravenous infusion, typically diluted in a compatible IV fluid. Administration details, including infusion time and dilution volume, are defined by the prescribing clinician.

Serious risks include severe allergic reactions such as anaphylaxis, Clostridio‑C​ ​  ​  ​  ​  ​  ​  ​  ​  ​  ​  ​  ​  ​  ​  ​  ​  ​  ​  ​  ​  ​  ​  ​  ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​

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GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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