Product image of Paosonelle (Drospirenone, Estradiol Hemihydrate) supplied by GNH India

Paosonelle

Active Ingredient:
Drospirenone, Estradiol Hemihydrate
Origin:
EU

Paosonelle (Drospirenone, Estradiol Hemihydrate)

Drospirenone, the active ingredient in Paosonelle, is a combined hormonal contraceptive presented as a tablet for oral use. It treats hormonal imbalances and related conditions in women of reproductive age. GNH India supplies Paosonelle as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

GNH India supplies Paosonelle as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

Paosonelle, a combined estrogen‑progestin preparation, is used in hormone‑replacement therapy pathways.

  • Menopause symptom relief: Improves vasomotor symptoms and prevents bone loss.
  • Hypo‑estrogenism due to ovarian insufficiency: Restores estrogen levels and alleviates related symptoms.
  • Contraception: Provides reliable prevention of pregnancy when taken as directed.

How It Works

  • Drospirenone acts as a progestogenic agent with anti‑aldosterone activity, while estradiol hemihydrate provides estrogenic stimulation. Together they bind to progesterone and estrogen receptors, suppressing ovulation, stabilising the endometrial lining and alleviating estrogen‑deficiency symptoms.

Side Effects

Adverse reactions may occur with any hormonal product. Monitoring and patient education are essential.

Common Side Effects

  • Nausea
  • Headache
  • Breast tenderness
  • Weight gain
  • Mood changes
  • Irregular vaginal bleeding

Serious or Rare Side Effects

  • Deep vein thrombosis
  • Pulmonary embolism
  • Stroke
  • Myocardial infarction
  • Severe allergic reaction (anaphylaxis)
  • Hepatotoxicity

Precautions & Warnings

When prescribing Paosonelle, clinicians should consider several safety aspects.

  • Thromboembolic risk: Assess patient history of clotting disorders.
  • Cardiovascular health: Evaluate blood pressure and lipid profile.
  • Liver function: Monitor hepatic enzymes in patients with liver disease.
  • Smoking status: Advise against use in smokers over 35 years old.
  • Pregnancy and lactation: Contraindicated during pregnancy and breastfeeding.
  • Store at ambient temperature: Keep below 25°C in the original packaging, protected from moisture.

Avoid Interactions

Paosonelle can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers:  
  • Strong  

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Moderate  

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Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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