Product image of Paracet (Paracetamol) supplied by GNH India

Paracet

Active Ingredient:
Paracetamol
Origin:
EU

Paracet (Paracetamol)

Paracetamol, the active ingredient in Paracet, is an analgesic presented as a suppository for rectal use. It treats pain and fever in patients who require an alternative to oral administration.

GNH India supplies Paracet as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Karo Pharma As

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Indications & Clinical Uses

Paracet is an analgesic and antipyretic that works within the body's pain‑and‑temperature regulation pathways.

  • Pain: Reduces mild to moderate pain such as headache, toothache, or musculoskeletal discomfort.
  • Fever: Lowers elevated body temperature associated with infection or inflammation.
  • Post‑operative discomfort: Provides analgesia when oral intake may be limited.

How It Works

  • Paracetamol exerts its effect by inhibiting prostaglandin synthesis in the central nervous system, primarily through action on the cyclooxygenase pathway. This reduces the perception of pain and resets the hypothalamic set‑point for temperature regulation, producing analgesic and antipyretic outcomes.

Side Effects

Paracet may cause adverse reactions, most of which are dose‑related or idiosyncratic.

Common Side Effects

  • Nausea: Mild stomach upset may occur.
  • Rash: Skin redness or mild itching.
  • Local irritation: Discomfort at the site of suppository insertion.

Serious or Rare Side Effects

  • Hepatotoxicity: Potential liver injury with excessive exposure.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Anaphylaxis: Rare, life‑threatening allergic response.
  • Blood disorders: Aplastic anemia or thrombocytopenia in very rare cases.

Precautions & Warnings

When using Paracet, consider the following safety measures:

  • Dose limitation: Do not exceed the total daily paracetamol amount recommended for all sources.
  • Liver function: Avoid use in patients with severe hepatic impairment or active liver disease.
  • Alcohol use: Limit alcohol consumption as it may increase liver risk.
  • Age restrictions: Use with caution in children and the elderly.
  • Storage: Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Paracet can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Warfarin: Increased risk of bleeding due to enhanced anticoagulant effect.
  • Isoniazid: Heightened risk of liver toxicity.

Moderate Interactions (Monitor Closely)

  • Antiepileptic drugs (e.g., carbamazepine, phenytoin): May reduce paracetamol plasma levels.
  • Certain HIV protease inhibitors: May increase paracetamol concentrations.
  • Alcohol: Combined use can amplify hepatotoxic potential.

Frequently Asked Questions

Paracet is a rectal suppository that contains paracetamol, an analgesic and antipyretic. It is used to relieve mild to moderate pain and to lower fever when oral administration is not suitable or preferred.

Paracetamol works by inhibiting prostaglandin synthesis in the central nervous system, which reduces the perception of pain and helps reset the hypothalamic set‑point that controls body temperature, providing both analgesic and antipyretic effects.

The appropriate dose of Paracet is determined by a qualified prescriber based on the patient’s age, weight, clinical condition and total daily intake of paracetamol from all sources.

Paracetamol is generally considered the preferred analgesic/antipyretic in pregnancy, but safety data for the rectal form are limited. Use should be under medical advice, and breastfeeding mothers should follow professional guidance.

To order Paracet, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Paracet offers a rectal delivery option, which can be advantageous when patients cannot swallow oral tablets or liquids. Its efficacy and safety profile are comparable to other paracetamol formulations, though onset of action may differ due to the suppository route.

Paracet should be stored at room temperature, protected from moisture and direct sunlight, and kept in its original packaging until use to maintain product stability.

Paracet is inserted rectally, preferably after a bowel movement. The suppository should be placed gently into the rectum with the tip pointing upward, allowing it to melt and release the medication.

The most serious risks include potential liver toxicity, especially with excessive dosing or pre‑existing liver disease, and rare severe skin reactions such as Stevens‑Johnson syndrome. Prompt medical attention is required if these occur.

Paracet should be avoided by individuals with known hypersensitivity to paracetamol, severe liver impairment, or those who have experienced serious adverse reactions to paracetamol or other analgesics.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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