Product image of Paracetamol supplied by GNH India

Paracetamol

Active Ingredient:
Paracetamol
Origin:
EU

Paracetamol

Paracetamol, the active ingredient in Paracetamol injection, is an analgesic presented as an injection solution for intravenous infusion use. It provides relief from pain and reduces fever in patients of all ages when administered under medical supervision. It is commonly used in surgical settings, emergency departments, and postoperative care to manage acute discomfort and febrile responses.

GNH India supplies Paracetamol injection as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for each batch.

Manufacturer / TM Owner

Ibi G. Lorenzini Spa

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Indications & Clinical Uses

Paracetamol is an analgesic and antipyretic that reduces pain and fever by acting on the central prostaglandin pathway.

  • Pain: provides analgesic effect to relieve mild to moderate pain.
  • Fever: lowers elevated body temperature.
  • Post‑operative discomfort: helps control pain after surgery.

How It Works

  • Paracetamol exerts its analgesic and antipyretic actions primarily through inhibition of cyclooxygenase enzymes in the central nervous system, leading to reduced synthesis of prostaglandins that mediate pain and thermoregulation. This central inhibition occurs without significant peripheral anti‑inflammatory activity.

Side Effects

Paracetamol injection may cause adverse reactions, most of which are mild and transient.

Common Side Effects

  • Injection site pain: discomfort at the site of administration.
  • Transient hypotension: temporary drop in blood pressure.
  • Nausea: feeling of sickness or urge to vomit.
  • Rash: mild skin irritation or redness.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.
  • Severe hepatic injury: potential liver damage, especially with overdose.
  • Stevens‑Johnson syndrome: rare, serious skin disorder.
  • Blood dyscrasias: abnormal blood cell counts or function.

Precautions & Warnings

When using Paracetamol injection, consider the following safety measures.

  • Assess liver function: check baseline hepatic enzymes before prolonged use.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Monitor renal function: adjust in patients with renal impairment.
  • Use lowest effective dose: limit duration to reduce risk of hepatotoxicity.
  • Pregnancy and lactation: evaluate risk–benefit; consult healthcare provider.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Paracetamol may interact with other medicines; review the following categories.

Major Interactions (Avoid)

  • Concomitant use with other hepatotoxic drugs (e.g., high‑dose acetaminophen, isoniazid) may increase liver injury risk.
  • Co‑administration with anticoagulants (warfarin) can enhance bleeding risk.
  • Interaction with enzyme inducers (rifampicin) may reduce efficacy.

Moderate Interactions (Monitor Closely)

  • Use with alcohol may increase hepatotoxic potential.
  • Combination with other antipyretics (ibuprofen) may increase gastrointestinal irritation.
  • Concurrent use with certain anticonvulsants (carbamazepine) may alter metabolism.

Frequently Asked Questions

Paracetamol injection is used to provide rapid relief of pain and to reduce fever in patients when an intravenous route is required, such as in surgical, emergency or postoperative settings.

Paracetamol works by inhibiting cyclooxygenase enzymes in the central nervous system, which decreases the production of prostaglandins that signal pain and regulate body temperature, resulting in analgesic and antipyretic effects.

The appropriate dose of Paracetamol injection is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and treatment setting.

Safety in pregnancy and lactation should be evaluated by a qualified healthcare provider. Paracetamol is generally considered low risk, but the prescriber must weigh potential benefits against any possible risks.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Paracetamol injection offers rapid onset via the intravenous route, making it useful when oral administration is not feasible. Compared with non‑steroidal anti‑inflammatory drugs, it has less gastrointestinal irritation but does not provide anti‑inflammatory effects.

Paracetamol injection should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen or shaken. Follow the manufacturer’s instructions for handling and reconstitution.

The product is administered as an intravenous infusion by a qualified healthcare professional, following aseptic technique and the prescribed infusion rate and volume.

Serious risks include anaphylactic reactions, severe hepatic injury especially with overdose, and rare skin disorders such as Stevens‑Johnson syndrome. Immediate medical attention is required if any of these occur.

Patients with known hypersensitivity to paracetamol or any component of the formulation, those with severe liver disease, or individuals for whom the risk outweighs the benefit should avoid this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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