Product image of Paracetamol supplied by GNH India

Paracetamol

Active Ingredient:
Paracetamol
Origin:
EU

Paracetamol

Paracetamol, the active ingredient in Paracetamol, is an analgesic and antipyretic presented as a standard oral dosage form for oral use. It relieves mild to moderate pain and reduces fever in adults and children when directed by a healthcare professional.

GNH India supplies Paracetamol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU quality standards and is manufactured under GMP conditions.

Manufacturer / TM Owner

Pxg Pharma Gmbh

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Indications & Clinical Uses

Paracetamol acts on the central pain and temperature pathways to provide symptomatic relief.

  • Pain: alleviates mild to moderate acute or chronic pain such as headache, dental or musculoskeletal discomfort.
  • Fever: lowers elevated body temperature associated with infection or inflammatory conditions.
  • Headache: reduces the intensity of tension‑type or migraine‑related headache.
  • Osteoarthritis: helps manage pain associated with osteoarthritic joints.

How It Works

  • Paracetamol inhibits cyclooxygenase enzymes, primarily COX‑2, within the central nervous system, leading to reduced synthesis of prostaglandins that mediate pain and fever. This central inhibition occurs without significant peripheral anti‑inflammatory activity, allowing effective analgesia and antipyresis while sparing gastric mucosa.

Side Effects

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: mild stomach upset experienced by some users.
  • Rash: transient skin redness or itching.
  • Abdominal discomfort: mild stomach pain or dyspepsia.
  • Headache: occasional worsening of head pain.
  • Dizziness: brief sensation of light‑headedness.
  • Sweating: increased perspiration without exertion.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reaction requiring immediate medical attention.
  • Liver toxicity: elevated liver enzymes or hepatic failure, especially with overdose.
  • Blood disorders: rare cases of agranulocytosis or thrombocytopenia.
  • Anaphylaxis: life‑threatening allergic reaction.
  • Severe skin reactions: toxic epidermal necrolysis.
  • Blood dyscrasias: rare hemolytic anemia.

Precautions & Warnings

Paracetamol should be used with attention to specific safety considerations.

  • Dosage adjustment: reduce dose in patients with hepatic impairment.
  • Alcohol consumption: avoid excessive alcohol to reduce liver risk.
  • Age considerations: use pediatric formulations for children and monitor elderly patients.
  • Pregnancy: consult a healthcare professional before use during pregnancy.
  • Drug interactions: review all concomitant medications for potential interactions.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Paracetamol can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Warfarin: increased risk of bleeding.
  • Isoniazid: heightened potential for hepatotoxicity.
  • Carbamazepine: reduced analgesic efficacy.

Moderate Interactions (Monitor Closely)

  • Alcohol: additive liver toxicity risk.
  • Other hepatotoxic drugs: monitor liver function tests.
  • Phenobarbital: may increase paracetamol metabolism, lowering effectiveness.

Frequently Asked Questions

Paracetamol is used to relieve mild to moderate pain such as headache, dental pain, musculoskeletal discomfort, and to reduce fever associated with infections or inflammatory conditions. It provides symptomatic relief when directed by a healthcare professional.

Paracetamol works by inhibiting cyclooxygenase enzymes, mainly COX‑2, in the central nervous system. This reduces the production of prostaglandins that transmit pain signals and regulate body temperature, resulting in analgesic and antipyretic effects.

The appropriate dose of Paracetamol is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and any existing medical factors. Patients should follow the prescriber’s instructions and not exceed the recommended amount.

Paracetamol is generally considered compatible with pregnancy and breastfeeding when used at the lowest effective dose under medical guidance. However, pregnant or nursing individuals should consult their healthcare provider before starting treatment.

To order Paracetamol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with non‑steroidal anti‑inflammatory drugs (NSAIDs), Paracetamol provides analgesic and antipyretic effects without significant anti‑inflammatory activity or the gastrointestinal irritation associated with many NSAIDs. It is often chosen when NSAIDs are contraindicated or when a milder analgesic is sufficient.

Paracetamol should be stored at ambient temperature, below 25 °C, in its original container. Keep it away from moisture, direct sunlight, and out of reach of children. Do not use if the packaging is damaged or the product appears discolored.

Paracetamol is administered orally, typically as a tablet, capsule, or liquid formulation. The medication is swallowed with water and taken according to the prescriber’s directions, usually with or without food.

The most serious risks include liver toxicity, especially with overdose or when combined with alcohol or other hepatotoxic drugs, and rare severe skin reactions such as Stevens‑Johnson syndrome. Prompt medical attention is required if signs of liver injury or severe rash develop.

Paracetamol should be avoided by individuals with known hypersensitivity to the drug, severe liver disease, or those taking medications that may cause dangerous interactions without proper medical supervision. Pregnant or breastfeeding patients should seek professional advice before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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