Product image of Paracetamol supplied by GNH India

Paracetamol

Active Ingredient:
Paracetamol
Origin:
EU

Paracetamol

Paracetamol, the active ingredient in Paracetamol, is an Analgesic, Antipyretic presented as a tablet for oral use. It treats mild to moderate pain and fever in adults and children.

GNH India supplies Paracetamol as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

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Indications & Clinical Uses

  • Paracetamol acts on the prostaglandin pathway to relieve pain and reduce fever.
  • Headache: provides relief from mild to moderate headache pain.
  • Musculoskeletal pain: reduces discomfort associated with strains, sprains, and backache.
  • Fever: lowers elevated body temperature in febrile states.

How It Works

  • Paracetamol inhibits cyclooxygenase enzymes in the central nervous system, reducing the synthesis of prostaglandins that mediate pain and thermoregulation. This central inhibition lowers the pain threshold and resets the hypothalamic set‑point for body temperature, producing analgesic and antipyretic effects without significant peripheral anti‑inflammatory activity.

Side Effects

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea
  • Skin rash
  • Headache

Serious or Rare Side Effects

  • Severe liver injury (hepatotoxicity)
  • Blood disorders such as thrombocytopenia
  • Allergic reactions including anaphylaxis

Precautions & Warnings

  • Paracetamol should be used with attention to specific safety considerations.
  • Dose adjustment in liver disease: reduce dose or avoid if severe hepatic impairment.
  • Avoid exceeding recommended daily amount: do not surpass 4 g per day for adults.
  • Use with caution in alcohol consumers: increased risk of liver toxicity.
  • Monitor in renal impairment: dose may need adjustment in severe kidney disease.
  • Pregnancy and breastfeeding: consult a healthcare professional before use.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Paracetamol can interact with several medicines; awareness of major and moderate interactions helps ensure safe use.

Major Interactions (Avoid)

  • Alcohol: heightened risk of hepatotoxicity.
  • Warfarin: may enhance anticoagulant effect, increasing bleeding risk.
  • Carbamazepine: can reduce paracetamol's analgesic efficacy.

Moderate Interactions (Monitor Closely)

  • Isoniazid: potential additive liver stress.
  • Phenobarbital: may increase paracetamol metabolism, lowering effectiveness.
  • Phenytoin: may accelerate metabolism, requiring monitoring of pain control.

Frequently Asked Questions

Paracetamol is used to relieve mild to moderate pain such as headache, toothache, muscle aches, and to reduce fever associated with common infections. It is an over‑the‑counter option for adults and children when a non‑opioid analgesic is appropriate.

Paracetamol works by inhibiting cyclooxygenase enzymes in the brain and spinal cord, which decreases the production of prostaglandins that sensitize nerve endings to pain and raise the body’s temperature set‑point. This central action provides analgesic and antipyretic effects.

The specific dose of Paracetamol is determined by a prescriber or according to the product label. In general, adults may be advised to take up to 1 g per dose, not exceeding 4 g per day, while pediatric dosing is weight‑based. Always follow the healthcare professional’s instructions.

Paracetamol’s pregnancy category is listed as unknown, and safety data are limited. Healthcare providers usually consider it when benefits outweigh potential risks, but it should only be used under medical guidance during pregnancy or while breastfeeding.

To order Paracetamol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Paracetamol provides analgesic and antipyretic effects without significant anti‑inflammatory activity, whereas ibuprofen is a non‑steroidal anti‑inflammatory drug (NSAID) that also reduces inflammation. Ibuprofen may cause gastrointestinal irritation and affect platelet function, while Paracetamol carries a higher risk of liver toxicity at excessive doses.

Paracetamol tablets should be stored at ambient temperature, below 25 °C, in their original packaging to protect from moisture and light. Keep the container tightly closed and out of reach of children.

Paracetamol is administered orally, typically as a tablet, capsule, or liquid suspension. It should be swallowed with water, and the dosage form should be taken as directed by a healthcare professional or according to the product label.

The most serious risks include severe liver injury, especially when the maximum daily dose is exceeded or combined with alcohol, and rare allergic reactions such as anaphylaxis or severe skin disorders like Stevens‑Johnson syndrome. Prompt medical attention is required if symptoms of liver damage or a severe rash develop.

Paracetamol should be avoided by individuals with known hypersensitivity to the drug, those with severe hepatic impairment, and patients who have exceeded the recommended daily dose. Caution is also advised for people with chronic alcohol use or existing liver disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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