Product image of Paracetamol supplied by GNH India

Paracetamol

Active Ingredient:
Paracetamol
Origin:
EU

Paracetamol

Paracetamol, the active ingredient in Paracetamol, is an analgesic presented as a tablet for oral use. It relieves mild to moderate pain and reduces fever in adults and children.

GNH India supplies Paracetamol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pxg Pharma Gmbh

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Indications & Clinical Uses

Paracetamol acts as an analgesic and antipyretic, providing relief across common pain and fever pathways.

  • Pain: reduces mild to moderate acute pain such as headache, toothache or musculoskeletal discomfort.
  • Fever: lowers elevated body temperature associated with infection or inflammation.
  • Headache: alleviates tension‑type and migraine‑associated head pain.
  • Dental pain: eases postoperative or procedural dental discomfort.
  • Osteoarthritis: helps manage low‑grade joint pain in chronic conditions.

How It Works

  • Paracetamol inhibits cyclooxygenase enzymes, primarily COX‑2, within the central nervous system, reducing the synthesis of prostaglandins that mediate pain and fever. The peripheral anti‑inflammatory effect is minimal, allowing analgesic and antipyretic activity without significant anti‑inflammatory action.

Side Effects

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: mild stomach upset after ingestion.
  • Skin rash: transient erythema or mild itching.
  • Elevated liver enzymes: mild, reversible changes in laboratory tests.
  • Headache: occasional rebound headache.
  • Dizziness: brief sensation of light‑headedness.

Serious or Rare Side Effects

  • Hepatotoxicity: severe liver injury, especially with overdose or chronic alcohol use.
  • Stevens‑Johnson syndrome: rare severe skin reaction.
  • Blood dyscrasias: agranulocytosis or thrombocytopenia.
  • Anaphylaxis: immediate hypersensitivity reaction.
  • Renal impairment: acute kidney injury in susceptible individuals.

Precautions & Warnings

Paracetamol should be used with awareness of specific safety considerations.

  • Dose limitation: do not exceed the maximum daily amount recommended by a healthcare professional.
  • Alcohol use: avoid excessive alcohol, which can increase liver toxicity risk.
  • Liver disease: use cautiously in patients with existing hepatic impairment.
  • Drug interactions: review concomitant medications for potential additive hepatotoxicity.
  • Pregnancy and breastfeeding: consult a clinician before use during pregnancy or lactation.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Paracetamol can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Alcohol: combined use raises risk of liver damage.
  • Warfarin: may potentiate anticoagulant effect, increasing bleeding risk.
  • Carbamazepine: enzyme induction can lower paracetamol plasma levels, reducing efficacy.

Moderate Interactions (Monitor Closely)

  • Isoniazid: additive hepatotoxic potential.
  • Rifampicin: may increase metabolism, decreasing analgesic effect.
  • Other hepatotoxic drugs (e.g., certain antituberculars): monitor liver function tests.
  • High‑dose vitamin C: may affect renal clearance.
  • Oral contraceptives: slight increase in hepatic enzyme activity, monitor for reduced effectiveness.

Frequently Asked Questions

Paracetamol is used to relieve mild to moderate pain such as headache, toothache, musculoskeletal discomfort, and to reduce fever associated with infections or inflammatory conditions. It is commonly employed in both adult and pediatric populations for short‑term symptom control.

Paracetamol works by inhibiting cyclooxygenase enzymes, especially COX‑2, within the central nervous system. This reduces the production of prostaglandins, which are chemical messengers that sensitize nerve endings to pain and trigger fever responses, thereby providing analgesic and antipyretic effects.

The appropriate dose of Paracetamol is determined by a prescriber based on the patient’s age, weight, clinical condition, and any existing health concerns. Healthcare professionals set the exact amount and frequency to ensure safe and effective use.

Paracetamol is generally considered compatible with pregnancy and lactation when used at recommended doses, but a healthcare provider should be consulted before use. The prescriber will evaluate the benefits and any potential risks for both mother and child.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Paracetamol differs from non‑steroidal anti‑inflammatory drugs (NSAIDs) by having minimal anti‑inflammatory activity and a lower risk of gastrointestinal irritation. Unlike opioids, it does not cause dependence. Its safety profile makes it a first‑line option for mild to moderate pain and fever when NSAIDs are contraindicated.

Paracetamol tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture, heat and direct sunlight to maintain potency throughout the shelf life.

Paracetamol is taken orally, usually as a tablet that is swallowed whole with water. The dosage form is designed for rapid absorption, and the medication should be taken as directed by a healthcare professional.

The most serious risk is hepatotoxicity, which can lead to acute liver failure, especially after overdose or when combined with excessive alcohol. Rare but severe reactions include Stevens‑Johnson syndrome, anaphylaxis, and blood disorders such as agranulocytosis.

Paracetamol should be avoided by individuals with known hypersensitivity to the drug, severe liver disease, or those who have experienced serious adverse reactions previously. Patients taking multiple hepatotoxic agents should consult a clinician before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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