Product image of Paracetamol supplied by GNH India

Paracetamol

Active Ingredient:
Paracetamol
Origin:
EU

Paracetamol

Paracetamol, the active ingredient in Paracetamol, is an analgesic and antipyretic presented as an oral formulation for oral use. It provides relief from mild to moderate pain such as headache, muscular aches, and reduces fever in both adults and children.

GNH India supplies Paracetamol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides reliable sourcing for bulk and retail needs. Products are manufactured under GMP conditions and undergo rigorous testing to ensure safety and efficacy.

Manufacturer / TM Owner

Galenicum Vitae Slu

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Indications & Clinical Uses

  • Paracetamol is used to manage pain and fever by acting on the central nervous system.
  • Headache: alleviates pain associated with tension or migraine.
  • Fever: lowers elevated body temperature in infections or inflammatory conditions.
  • Muscular aches: reduces discomfort from strain or overuse.
  • Toothache: provides temporary relief of dental pain.
  • Arthralgia: eases joint pain associated with osteoarthritis.

How It Works

  • Paracetamol exerts its effect primarily by inhibiting cyclooxygenase enzymes, particularly COX‑2, within the central nervous system. This reduces the synthesis of prostaglandins that sensitize pain receptors and mediate fever. Unlike non‑steroidal anti‑inflammatory drugs, its peripheral anti‑inflammatory activity is minimal, allowing analgesic and antipyretic actions without significant impact on platelet function or gastric mucosa.

Side Effects

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: mild stomach upset that may occur after ingestion.
  • Abdominal discomfort: transient pain or fullness in the stomach area.
  • Rash: skin redness or mild itching.
  • Headache: occasional worsening of head pain.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reaction requiring immediate medical attention.
  • Anaphylaxis: rare allergic response with difficulty breathing or swelling.
  • Hepatotoxicity: liver injury, especially with overdose or chronic use.
  • Blood disorders: rare cases of thrombocytopenia or leukopenia.

Precautions & Warnings

  • When using Paracetamol, consider the following safety measures.
  • Dose adjustment: use lower doses in patients with hepatic impairment.
  • Alcohol use: avoid excessive alcohol as it increases hepatotoxic risk.
  • Age: consult a healthcare professional for children under 12 years.
  • Concurrent medications: review use with other hepatotoxic drugs.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Paracetamol may interact with other medicines; review the following.

Major Interactions (Avoid)

  • Warfarin: increased bleeding risk due to enhanced anticoagulant effect.
  • Isoniazid: heightened risk of liver toxicity.
  • Carbamazepine: may increase hepatotoxicity.
  • Phenobarbital: may reduce analgesic effect.

Moderate Interactions (Monitor Closely)

  • Alcohol: may potentiate liver injury.
  • NSAIDs: additive toxicity to liver and kidneys.
  • Antiepileptics (phenytoin): possible enzyme induction affecting drug levels.

Frequently Asked Questions

Paracetamol is an over‑the‑counter analgesic and antipyretic used to relieve mild to moderate pain such as headache, toothache, muscular aches, and to reduce fever associated with infections or inflammatory conditions.

Paracetamol works by inhibiting cyclooxygenase enzymes in the central nervous system, which lowers the production of prostaglandins that sensitize pain receptors and trigger fever, thereby providing analgesic and antipyretic effects.

The appropriate dose of Paracetamol is determined by a prescriber or pharmacist based on the patient’s age, weight, and clinical condition. Always follow the specific dosing instructions provided on the product label or by a healthcare professional.

Paracetamol is generally considered compatible with pregnancy and breastfeeding when used at recommended doses, but a healthcare professional should be consulted to confirm safety for the individual situation.

To order Paracetamol, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with non‑steroidal anti‑inflammatory drugs (NSAIDs), Paracetamol provides effective pain relief and fever reduction without significant anti‑inflammatory activity, gastrointestinal irritation, or impact on platelet function, making it a preferred option for patients who need a milder safety profile.

Paracetamol should be stored at ambient temperature, below 25 °C, in its original packaging. Keep it away from moisture, direct sunlight, and out of reach of children to maintain product stability.

Paracetamol is administered orally, typically as a tablet, capsule, or liquid formulation. It should be taken with or without food as directed by a healthcare professional.

The most serious risks include severe liver injury (hepatotoxicity), especially with overdose or chronic high‑dose use, and rare severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Paracetamol should be avoided by individuals with known severe liver disease, hypersensitivity to the drug, or those who are taking other medications that may cause dangerous liver interactions without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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