Product image of Paracetamol supplied by GNH India

Paracetamol

Active Ingredient:
Paracetamol
Origin:
EU

Paracetamol

Paracetamol, the active ingredient in Paracetamol, is an Analgesic presented as an oral tablet for oral use. It provides effective pain relief and reduces fever across a broad patient population, including adults and children, when used according to professional guidance.

GNH India supplies Paracetamol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory conformity for global healthcare providers and reliable product availability across diverse markets.

Manufacturer / TM Owner

Medley Pharma Limited

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Indications & Clinical Uses

Paracetamol is an analgesic and antipyretic used to manage common pain and fever conditions.

  • Headache: relief of pain associated with tension‑type or migraine headaches.
  • Fever: reduction of elevated body temperature in infectious or inflammatory states.
  • Musculoskeletal pain: alleviation of aches and soreness in muscles, joints and back.
  • Toothache: mitigation of dental pain following procedures or infection.

How It Works

  • Paracetamol acts primarily by inhibiting cyclooxygenase enzymes in the central nervous system, which reduces the synthesis of prostaglandins involved in pain perception and thermoregulation. This central COX inhibition leads to analgesic and antipyretic effects without significant peripheral anti‑inflammatory activity.

Side Effects

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Abdominal discomfort: occasional stomach pain.
  • Rash: mild skin irritation or itching.
  • Headache: paradoxical headache in some users.

Serious or Rare Side Effects

  • Hepatotoxicity: severe liver injury, especially with overdose.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: rare severe skin reactions.
  • Blood disorders: agranulocytosis or thrombocytopenia in very rare cases.

Precautions & Warnings

When using Paracetamol, consider the following safety measures.

  • Dose adjustment in liver disease: reduce dose or avoid use in severe hepatic impairment.
  • Avoid in severe renal impairment: monitor renal function and limit exposure.
  • Do not exceed recommended daily amount: adhere to maximum 4 g per day for adults.
  • Use caution with alcohol: concurrent intake may increase liver toxicity risk.
  • Pregnancy and breastfeeding: consult a healthcare professional before use.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Paracetamol may interact with other medicines; monitor as indicated.

Major Interactions (Avoid)

  • Concurrent use with other hepatotoxic drugs: increased risk of liver injury.
  • Alcohol consumption: potentiates hepatic toxicity.
  • Warfarin: may enhance anticoagulant effect and increase bleeding risk.

Moderate Interactions (Monitor Closely)

  • Carbamazepine: may reduce paracetamol plasma concentrations.
  • Phenytoin: may decrease analgesic efficacy.
  • Rifampicin: may increase metabolism leading to lower effectiveness.

Frequently Asked Questions

Paracetamol is an over‑the‑counter medication used to relieve mild to moderate pain such as headaches, toothaches, muscle aches, and to reduce fever associated with infections or inflammatory conditions.

Paracetamol works by inhibiting cyclooxygenase enzymes in the central nervous system, which lowers the production of prostaglandins that mediate pain and regulate body temperature, providing analgesic and antipyretic effects.

The appropriate dose of Paracetamol is determined by a prescriber or according to the product labeling, taking into account the patient’s age, weight, liver function and any other relevant clinical factors.

Safety of Paracetamol in pregnancy and lactation is not fully established; it should only be used when clearly needed and after consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Paracetamol provides analgesic and antipyretic effects without significant anti‑inflammatory activity, whereas ibuprofen is a non‑steroidal anti‑inflammatory drug (NSAID) that also reduces inflammation. Choice depends on the clinical need, patient tolerance and safety profile.

Paracetamol tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep out of reach of children.

Paracetamol is taken orally, usually as a tablet or liquid, and should be swallowed with water. The exact method of administration follows the instructions provided by the prescriber or product label.

The most serious risk is hepatotoxicity, which can lead to acute liver failure, especially when the maximum daily dose is exceeded or combined with other liver‑toxic substances such as alcohol.

Paracetamol should be avoided in individuals with known hypersensitivity to the drug, severe liver disease, or those who have exceeded the recommended daily dose. Caution is also advised for patients with chronic alcohol use or certain metabolic disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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