Paracetamol Dinepar Laboratórios Azevedos - Indústria Farmacêutica (Paracetamol)

Paracetamol is an analgesic and antipyretic that acts on the central nervous system to relieve pain and lower temperature.

• Fever: Reduces elevated body temperature in acute and chronic febrile states.
• Headache: Alleviates tension‑type and mild migraine headaches.
• Musculoskeletal pain: Relieves mild to moderate pain from muscle strains, sprains and backache.
• Dental pain: Provides relief from postoperative dental discomfort.
• Osteoarthritis: Helps manage mild pain associated with osteoarthritis.

• Paracetamol exerts its effect primarily by inhibiting the cyclooxygenase (COX) enzymes in the central nervous system, especially COX‑2, which reduces the synthesis of prostaglandins involved in pain signalling and thermoregulation. It also modulates serotonergic pathways that contribute to its antipyretic action, without significant peripheral anti‑inflammatory activity.

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

• Nausea: Mild stomach upset may be reported.
• Rash: Occasional skin redness or mild itching.
• Elevated liver enzymes: Transient increase detected in laboratory tests.
• Headache: Paradoxical headache in a small number of users.
• Dizziness: Light‑headed sensation, especially with rapid dose escalation.

Serious or Rare Side Effects

• Stevens‑Johnson syndrome: Severe skin reaction requiring immediate medical attention.
• Toxic hepatitis: Liver injury that may present with jaundice, fatigue and abdominal pain.
• Anaphylaxis: Rare systemic allergic reaction with hives, swelling and breathing difficulty.
• Blood dyscrasias: Uncommon blood cell abnormalities such as agranulocytosis.
• Renal impairment: Acute kidney injury in susceptible individuals.
• Hypersensitivity reactions: Swelling of lips, tongue or throat.

Paracetamol should be used with awareness of its safety profile and potential interactions.

• Dose limitation: Do not exceed the maximum daily amount recommended by a healthcare professional.
• Liver health: Avoid use in patients with severe hepatic impairment or active liver disease.
• Alcohol consumption: Limit alcohol intake while taking this medication to reduce liver stress.
• Pregnancy and lactation: Use only when clearly indicated; consult a healthcare provider.
• Pediatric use: Ensure appropriate weight‑based dosing for children; do not give adult formulations to pediatric patients.
• Store at ambient temperature: Keep the tablets in the original container, protected from moisture and direct sunlight.

ParacetamO may interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

• Warfarin: Increases risk of bleeding  

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