Paracetamol 500 Mg Hexal Bei Fieber Und Schmerzen (Paracetamol)

• Paracetamol is an analgesic and antipyretic that reduces fever and alleviates mild to moderate pain.
• Fever: lowers elevated body temperature and improves comfort.
• Headache: relieves tension‑type headache symptoms.
• Musculoskeletal pain: eases aches associated with muscle strain or minor injury.
• Dental pain: provides relief from toothache and postoperative dental discomfort.
• Cold/flu symptoms: helps control discomfort such as sore throat and body aches during viral upper respiratory infections.

• Paracetamol acts centrally by inhibiting cyclooxygenase (COX) enzymes, primarily COX‑2, which reduces the synthesis of prostaglandins in the brain and spinal cord. This decrease in prostaglandin levels diminishes the perception of pain and lowers the hypothalamic set‑point for body temperature, producing antipyretic and analgesic effects without significant peripheral anti‑inflammatory activity.

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

• Nausea: mild stomach upset after ingestion.
• Abdominal discomfort: occasional stomach pain or indigestion.
• Rash: skin redness or mild itching.
• Sweating: increased perspiration without exertion.
• Headache: transient headache in some individuals.
• Dizziness: brief feeling of light‑headedness.

Serious or Rare Side Effects

• Stevens‑Johnson syndrome: severe skin reaction requiring immediate medical attention.
• Liver toxicity: elevated liver enzymes or hepatic failure, especially with overdose.
• Blood disorders: rare cases of agranulocytosis or thrombocytopenia.
• Anaphylaxis: life‑threatening allergic reaction with breathing difficulty.
• Severe skin reactions: toxic epidermal necrolysis or drug reaction with eosinophilia and systemic symptoms (DRESS).

• Paracetamol should be used with awareness of specific safety considerations.
• Assess liver function: avoid in patients with severe hepatic impairment.
• Limit alcohol: concurrent alcohol consumption increases risk of liver injury.
• Use lowest effective dose: follow prescriber guidance to minimise toxicity.
• Monitor in pregnancy: discuss potential risks with a healthcare professional.
• Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
• Store at ambient temperature: keep below 25 °C, protect from moisture and light.

Paracetamol can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

• Alcohol: combined use markedly raises risk of liver injury.
• Warfarin: paracetamol may potentiate anticoagulant effect, increasing bleeding risk.
• Carbamazepine: enzyme induction can lower paracetamol plasma levels, reducing analgesic effect.

Moderate Interactions (Monitor Closely)

• Isoniazid: concurrent use may increase hepatic toxicity; monitor liver enzymes.
• Oral contraceptives: may experience reduced contraceptive efficacy; advise additional protection.