Product image of Paracetamol Accel (Paracetamol) supplied by GNH India

Paracetamol Accel

Active Ingredient:
Paracetamol
Origin:
EU

Paracetamol Accel (Paracetamol)

Paracetamol, the active ingredient in Paracetamol Accel, is an analgesic presented as a rectal suppository for rectal administration. It is used to relieve mild to moderate pain and to reduce fever in both adult and pediatric patients.

GNH India supplies Paracetamol Accel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our production adheres to EU pharmacopeial standards, and the product is packaged to preserve stability throughout global distribution. We also provide temperature‑controlled logistics where required to ensure product integrity.

Manufacturer / TM Owner

Bene Farmacêutica, Lda.

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Indications & Clinical Uses

Paracetamol is an analgesic/antipyretic that acts on the prostaglandin pathway to relieve pain and fever.

  • Mild to moderate pain: provides effective analgesic relief.
  • Fever: reduces elevated body temperature.
  • Headache: alleviates tension‑type headache.
  • Dental pain: eases postoperative discomfort.
  • Musculoskeletal pain: helps manage aches from strain.

How It Works

  • Paracetamol exerts its analgesic and antipyretic actions primarily by inhibiting cyclooxygenase (COX) enzymes in the central nervous system, which reduces the synthesis of prostaglandins involved in pain signaling and thermoregulation. This central inhibition occurs without significant peripheral anti‑inflammatory activity.

Side Effects

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea
  • Rash or mild skin irritation
  • Dizziness
  • Transient elevation of liver enzymes

Serious or Rare Side Effects

  • Severe hepatotoxicity, especially with overdose
  • Anaphylactic or severe allergic reactions
  • Blood disorders such as agranulocytosis or thrombocytopenia

Precautions & Warnings

Paracetamol should be used with caution in specific situations.

  • Do not exceed recommended dose: risk of liver injury.
  • Avoid use with other paracetamol‑containing products: cumulative toxicity.
  • Caution in patients with pre‑existing liver disease: monitor hepatic function.
  • Use with care in chronic alcohol users: increased hepatotoxic risk.
  • Pregnancy and breastfeeding: consult a healthcare professional before use.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Paracetamol may interact with several medicines; awareness of major and moderate interactions helps ensure safety.

Major Interactions (Avoid)

  • Concurrent use with strong CYP450 inducers (e.g., rifampicin): reduced efficacy.
  • Co‑administration with warfarin: increased bleeding risk.
  • Combination with other hepatotoxic drugs (e.g., isoniazid): heightened liver toxicity.

Moderate Interactions (Monitor Closely)

  • Alcohol consumption: may increase liver strain.
  • Other NSAIDs: additive gastrointestinal irritation.
  • Antiepileptic drugs (e.g., carbamazepine): may lower paracetamol plasma levels.

Frequently Asked Questions

Paracetamol Accel is a rectal formulation of paracetamol indicated for the relief of mild to moderate pain and for the reduction of fever. It is commonly employed in both adult and pediatric patients when oral administration is not feasible or preferred.

Paracetamol works by inhibiting cyclooxygenase enzymes in the central nervous system, which decreases the production of prostaglandins that mediate pain and fever. This central action provides analgesic and antipyretic effects without significant peripheral anti‑inflammatory activity.

The appropriate dose of Paracetamol Accel is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and any relevant medical history. Dosage instructions are individualized and should be followed exactly as prescribed.

Paracetamol is generally considered compatible with pregnancy and lactation when used at recommended doses, but safety depends on individual circumstances. Women who are pregnant or breastfeeding should consult their healthcare provider before using Paracetamol Accel to confirm that it is appropriate for them.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

The primary alternative to paracetamol is the non‑steroidal anti‑inflammatory drug (NSAID) class, such as ibuprofen. Unlike NSAIDs, paracetamol lacks significant anti‑inflammatory activity but has a lower risk of gastrointestinal irritation and does not affect platelet function, making it suitable for patients who cannot tolerate NSAIDs.

Paracetamol Accel should be stored at room temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. No special refrigeration is required, but the product should be kept away from extreme heat and humidity to maintain its stability.

Paracetamol Accel is administered rectally. The suppository is inserted into the rectum, preferably after bowel movements, and held in place for a few minutes to allow complete dissolution and absorption of the active ingredient.

The most serious risks include severe liver injury (hepatotoxicity) that can occur with overdose or chronic high‑dose use, and rare but potentially life‑threatening allergic reactions such as anaphylaxis. Patients should avoid exceeding the recommended dose and seek immediate medical attention if signs of liver dysfunction or severe allergy appear.

Paracetamol Accel should be avoided by individuals with known hypersensitivity to paracetamol or any excipients in the suppository, patients with severe hepatic impairment, and those who have taken other paracetamol‑containing products that could lead to an excessive total dose.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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