Paracetamol Accord Healthcare (Paracetamol)

Paracetamol is used across several pain‑related pathways and fever mechanisms.

• Headache: provides relief from mild to moderate tension‑type headaches.
• Fever: lowers elevated body temperature associated with infections.
• Musculoskeletal pain: eases discomfort from muscle aches, strains and minor joint pain.
• Dental pain: reduces pain following dental procedures.
• Post‑operative pain: helps manage mild pain after minor surgical procedures.

• Paracetamol exerts its analgesic and antipyretic actions primarily by inhibiting cyclo‑cyclooxygenase (COX) enzymes in the central nervous system, which reduces prostaglandin synthesis. This central inhibition lowers the pain‑signal transmission and the hypothalamic set‑point for temperature regulation, providing relief from pain and fever without significant peripheral anti‑inflammatory effects.

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

• Nausea
• Abdominal discomfort
• Rash
• Elevated liver enzymes

Serious or Rare Side Effects

• Severe skin reactions such as Stevens‑Johnson syndrome
• Hepatotoxicity, especially with overdose
• Anaphylaxis
• Blood disorders (e.g., thrombocytopenia)

When using Paracetamol, consider the following safety measures:

• Dosage Limits: Adhere to recommended maximum daily dose to avoid liver toxicity.
• Liver Function: Monitor liver function in patients with existing hepatic impairment.
• Alcohol Use: Limit alcohol consumption as it may increase risk of liver damage.
• Pregnancy and Breastfeeding: Use only if clearly indicated.
• Drug Interactions: Review the   
• Store at ambient temperature: keep in the original packaging 

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