Product image of Paracetamol And Caffeine Nevik (Paracetamol, Caffeine) supplied by GNH India

Paracetamol And Caffeine Nevik

Active Ingredient:
Paracetamol, Caffeine
Origin:
EU

Paracetamol And Caffeine Nevik (Paracetamol, Caffeine)

Paracetamol, the active ingredient in Paracetamol And Caffeine Nevik, is an analgesic presented as a tablet for oral use. It is used to relieve mild to moderate pain and reduce fever in adults and children when appropriate. Paracetamol works together with caffeine, a central nervous system stimulant, to enhance analgesic effect.

GNH India supplies Paracetamol And Caffeine Nevik as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Nevik Limited

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Indications & Clinical Uses

Paracetamol and caffeine act as an analgesic and antipyretic, targeting common pain and fever pathways.

  • Headache: Reduces pain intensity and associated discomfort.
  • Fever: Lowers elevated body temperature in acute febrile states.
  • Musculoskeletal pain: Alleviates mild to moderate aches such as backache or toothache.
  • Menstrual discomfort: Diminishes cramping pain and associated headache.
  • Cold‑related symptoms: Relieves headache and fever accompanying upper respiratory infections.

How It Works

  • Paracetamol inhibits cyclo‑oxygenase enzymes (COX‑1 and COX‑2) primarily in the central nervous system, decreasing prostaglandin synthesis and thereby reducing pain and fever. Caffeine antagonises adenosine receptors, producing mild central stimulation and vasoconstriction, which enhances the analgesic effect of paracetamol and improves headache relief.

Side Effects

Paracetamol and caffeine are generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: Mild stomach upset or queasiness.
  • Insomnia: Difficulty falling or staying asleep.
  • Restlessness: Feeling jittery or uneasy.
  • Increased heart rate: Palpitations or tachycardia.
  • Gastro‑intestinal discomfort: Stomach pain or dyspepsia.
  • Headache rebound: Occasional worsening of headache after use.

Serious or Rare Side Effects

  • Allergic reactions: Rash, itching, swelling, or anaphylaxis.
  • Hepatic injury: Elevated liver enzymes or liver failure, especially with overdose.
  • Stevens‑Johnson syndrome: Severe skin blistering and mucosal involvement.
  • Blood disorders: Thrombocytopenia or neutropenia.
  • Cardiovascular events: Hypertension or arrhythmia in susceptible individuals.
  • Severe gastrointestinal bleeding: Rare but possible with concomitant anticoagulants.

Precautions & Warnings

Paracetamol and caffeine should be used with awareness of individual health status and potential risks.

  • Liver function: Avoid use in patients with severe hepatic impairment.
  • Pregnancy: Use only if clearly needed and prescribed by a healthcare professional.
  • Breastfeeding: Consider potential transfer to infant; consult a clinician.
  • Cardiovascular disease: Caution in patients with hypertension or arrhythmias.
  • Drug interactions: Review concomitant medications for possible interactions.
  • Store at ambient temperature: Keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Paracetamol and caffeine may interact with several medicines; monitoring is advised.

Major Interactions (Avoid)

  • Warfarin: Paracetamol can potentiate anticoagulant effect, increasing bleeding risk.
  • Carbamazepine: Induces metabolism, reducing paracetamol efficacy.
  • Monoamine oxidase inhibitors (MAOIs): Caffeine may cause hypertensive episodes.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: Paracetamol may increase hepatic enzyme activity, reducing contraceptive effectiveness.
  • Antiepileptic drugs (e.g., phenytoin): May alter caffeine clearance.
  • Lithium: Caffeine can increase lithium excretion, affecting serum levels.

Frequently Asked Questions

Paracetamol And Caffeine Nevik is an oral tablet that combines an analgesic (paracetamol) with a stimulant (caffeine). It is indicated for the relief of mild to moderate pain such as headache, toothache, musculoskeletal aches, and for the reduction of fever in adults and children when appropriate.

Paracetamol reduces pain and fever by inhibiting central cyclo‑oxygenase enzymes, which lowers prostaglandin production in the brain. This action diminishes the perception of pain and resets the hypothalamic temperature set‑point, resulting in antipyretic effect.

The specific dose and dosing interval are determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and any concomitant therapies. Healthcare professionals should follow local prescribing guidelines and adjust as needed.

Paracetamol is generally considered safe in pregnancy when used at recommended doses, but caffeine intake should be limited. Breastfeeding mothers should consult a healthcare provider, as both ingredients can be transferred to the infant in small amounts.

Enquiries can be submitted via the product page on gnhindia.com by entering the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The addition of caffeine to paracetamol can enhance analgesic efficacy, particularly for headache, by providing a synergistic effect. Standard paracetamol tablets lack this stimulant component, so the combination may offer faster or more pronounced pain relief in certain conditions.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture, humidity and direct sunlight. Do not use if the packaging is damaged or the tablets appear discoloured.

The product is taken orally with a glass of water. It can be taken with or without food, according to the prescriber’s instructions. Swallow the tablet whole; do not crush or chew unless specifically advised.

Serious risks include severe allergic reactions (anaphylaxis), hepatic injury especially with overdose, and rare skin disorders such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience rash, jaundice, unexplained bruising, or difficulty breathing.

Individuals with known hypersensitivity to paracetamol, caffeine, or any excipients should avoid this product. It is also contraindicated in patients with severe liver disease, uncontrolled hypertension, certain cardiac arrhythmias, or those taking monoamine oxidase inhibitors without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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