Paracetamol And Codeine The Boots Company

Active Ingredient:: Paracetamol, Codeine Phosphate
Origin:: EU

Paracetamol And Codeine The Boots Company (Paracetamol, Codeine Phosphate)

International sale not permitted. Listed for the domestic market and B2B only.

Paracetamol, the active ingredient in Paracetamol And Codeine The Boots Company, is an analgesic presented as an oral dosage form for oral use. It is combined with codeine phosphate to provide relief from mild to moderate pain and to reduce fever in adults, and is indicated for short‑term management of pain and fever.

GNH India supplies Paracetamol And Codeine The Boots Company as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets.

Manufacturer / TM Owner

The Boots Company Plc

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Indications & Clinical Uses

Paracetamol and codeine phosphate is used to manage pain and fever within the musculoskeletal and febrile disease families.

Mild to moderate pain: provides analgesia for conditions such as headache, dental pain, and musculoskeletal aches.
Fever: reduces elevated body temperature associated with infections.
Post‑operative pain: helps control discomfort after minor surgical procedures.

How It Works

Paracetamol exerts analgesic and antipyretic effects by inhibiting central cyclooxygenase-mediated prostaglandin synthesis, thereby reducing pain signaling and temperature regulation. Codeine phosphate is an opioid that binds to μ‑opioid receptors in the central nervous system, producing additional analgesia and a cough‑suppressant effect through neuronal inhibition.

Side Effects

Common Side Effects

Nausea: mild to moderate stomach upset.
Constipation: reduced bowel movements.
Drowsiness: feeling of sleepiness.
Dry mouth: reduced salivation.

Serious or Rare Side Effects

Respiratory depression: slowed breathing, especially at high doses.
Allergic reactions: rash, itching, swelling, or anaphylaxis.
Liver toxicity: elevated liver enzymes or hepatic injury with excessive use.
Dependence or abuse potential: risk of opioid dependence with prolonged use.
Severe hypotension: marked drop in blood pressure.

Precautions & Warnings

Paracetamol and codeine phosphate should be used with caution in the following situations:

Assess liver function before use: avoid in severe hepatic impairment.
Avoid in patients with respiratory depression: risk of additive respiratory suppression.
Use caution with alcohol: may increase central nervous system depression.
Do not exceed recommended duration: limit use to the shortest effective period.
Monitor for signs of dependence: watch for misuse or craving.
Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Paracetamol and codeine phosphate may interact with other medicines as follows:

Major Interactions (Avoid)

Other opioid analgesics: additive risk of respiratory depression.
Benzodiazepines: increased sedation and CNS depression.
Alcohol: enhanced central nervous system depression.

Moderate Interactions (Monitor Closely)

CYP2D6 inhibitors (e.g., fluoxetine): may increase codeine plasma levels.
CYP3A4 inducers (e.g., rifampicin): may reduce codeine effectiveness.
Anticoagulants (e.g., warfarin): may increase bleeding risk.

Frequently Asked Questions

Paracetamol And Codeine is a combination analgesic indicated for the short‑term relief of mild to moderate pain such as headache, dental discomfort, musculoskeletal aches, and for the reduction of fever associated with common infections.

Paracetamol acts centrally by inhibiting cyclooxygenase enzymes, which reduces the synthesis of prostaglandins involved in pain signaling and temperature regulation, thereby providing analgesic and antipyretic effects.

The appropriate dose is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and local prescribing guidelines. Patients should follow the prescriber’s instructions and not exceed the recommended amount.

Safety in pregnancy and lactation has not been fully established. It should only be used when the potential benefit outweighs the risk, and only under the guidance of a qualified healthcare professional.

Enquiries can be submitted on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with non‑opioid analgesics such as ibuprofen, the addition of codeine provides stronger pain relief but introduces opioid‑related risks like dependence and respiratory depression. It is often chosen when non‑opioid agents alone are insufficient.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use.

The medication is taken orally, usually as a tablet, and should be swallowed whole with a glass of water. It may be taken with or without food, according to the prescriber’s advice.

Serious risks include respiratory depression, especially in higher doses or when combined with other CNS depressants, potential for opioid dependence, severe allergic reactions, and liver toxicity if paracetamol is overdosed.

Individuals with severe hepatic impairment, uncontrolled asthma, significant respiratory depression, known hypersensitivity to either component, or those taking prohibited concomitant opioid medications should avoid this product. Pediatric use is restricted according to local regulations.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 13 Oct 2026

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International sale not permitted. Listed for the domestic market and B2B only.

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