Product image of Paracetamol And Phenylephrine Hydrochloride Thornton & Ross Ltd. (Phenylephrine Hydrochloride, Paracetamol) supplied by GNH India

Paracetamol And Phenylephrine Hydrochloride Thornton & Ross Ltd.

Active Ingredient:
Phenylephrine Hydrochloride, Paracetamol
Origin:
EU

Paracetamol And Phenylephrine Hydrochloride Thornton & Ross Ltd. (Phenylephrine Hydrochloride, Paracetamol)

Paracetamol and Phenylephrine hydrochloride, the active ingredients in Paracetamol And Phenylephrine Hydrochloride Thornton & Ross Ltd., are an analgesic and a decongestant presented as oral tablets for oral use. They relieve mild to moderate pain, reduce fever and alleviate nasal congestion in adults and children.

GNH India supplies Paracetamol And Phenylephrine Hydrochloride Thornton & Ross Ltd. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Thornton & Ross Ltd

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Indications & Clinical Uses

Paracetamol and Phenylephrine act together to address pain‑related and nasal‑congestion symptoms associated with common upper‑respiratory conditions.

  • Common cold: reduces nasal congestion, headache and fever.
  • Sinusitis: eases sinus pressure and associated pain.
  • Influenza‑like illness: provides analgesic relief and decongestant effect.

How It Works

  • Paracetamol exerts its analgesic and antipyretic action primarily by inhibiting central cyclo‑oxygenase enzymes, reducing prostaglandin synthesis in the brain. Phenylephrine hydrochloride is a selective α1‑adrenergic receptor agonist that causes vasoconstriction of the nasal mucosal vessels, decreasing swelling and improving airway patency.

Side Effects

Paracetamol and Phenylephrine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea
  • Dizziness
  • Headache
  • Insomnia
  • Dry mouth
  • Transient increase in blood pressure

Serious or Rare Side Effects

  • Anaphylactic reaction
  • Severe hepatic injury
  • Hypertensive crisis
  • Cardiac arrhythmia
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Severe bronchospasm

Precautions & Warnings

When using this combination product, consider the following safety measures.

  • Pregnancy: consult a healthcare professional before use.
  • Hypertension: monitor blood pressure regularly.
  • Liver disease: use with caution and under medical supervision.
  • Concomitant MAO inhibitors: avoid due to risk of hypertensive events.
  • Alcohol consumption: limit intake to reduce hepatic stress.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Paracetamol and Phenylephrine can interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs)
  • Other sympathomimetic agents (e.g., pseudoephedrine)
  • Additional paracetamol‑containing products (risk of overdose)

Moderate Interactions (Monitor Closely):\n- Antihypertensive drugs (may reduce efficacy)

  • Antidepressants (especially SSRIs)
  • Anticoagulants (potential for altered bleeding risk)
  • CYP450‑modulating agents (may affect paracetamol metabolism)

Frequently Asked Questions

Paracetamol And Phenylephrine Hydrochloride is a fixed‑dose oral tablet that combines an analgesic (paracetamol) with a nasal decongestant (phenylephrine). It is used to relieve mild to moderate pain, reduce fever, and alleviate nasal congestion associated with common colds, sinusitis, and flu‑like illnesses in adults and children.

Paracetamol works by inhibiting central cyclo‑oxygenase enzymes, which reduces the synthesis of prostaglandins in the brain. This action lowers the perception of pain and resets the body’s temperature‑regulating centre, providing analgesic and antipyretic effects.

The appropriate dose of Paracetamol And Phenylephrine Hydrochloride is determined by the prescribing healthcare professional based on the patient’s age, weight, and clinical condition. Patients should follow the prescriber’s instructions and not exceed the recommended amount.

Paracetamol is generally considered safe in pregnancy when used at recommended doses, but phenylephrine should be used only if clearly needed and after medical advice. Breastfeeding mothers should consult their doctor, as phenylephrine may pass into breast milk in small amounts.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will provide pricing, availability, shipping details (including any cold‑chain requirements) and assist with import documentation.

Compared with single‑ingredient products, this combination offers both analgesic and decongestant actions in one tablet, simplifying dosing. Unlike NSAID‑based analgesics, paracetamol has a lower risk of gastrointestinal irritation, while phenylephrine provides rapid nasal vasoconstriction without the rebound congestion seen with some older decongestants.

Store the tablets at room temperature, below 25 °C, in the original packaging. Keep them away from moisture, heat and direct sunlight to maintain potency and prevent degradation.

Paracetamol And Phenylephrine Hydrochloride is taken orally with a glass of water. It should be swallowed whole and not chewed or crushed, unless otherwise directed by a healthcare professional.

Serious risks include severe allergic reactions (anaphylaxis), hepatic injury from excessive paracetamol intake, hypertensive crisis or cardiac arrhythmia due to phenylephrine, and rare severe skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience any of these symptoms.

Individuals with known hypersensitivity to paracetamol, phenylephrine, or any excipients should avoid the product. It is also contraindicated in patients taking monoamine oxidase inhibitors, those with uncontrolled hypertension, severe liver disease, or certain cardiac conditions without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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