Product image of Paracetamol B. Braun (Paracetamol) supplied by GNH India

Paracetamol B. Braun

Active Ingredient:
Paracetamol
Origin:
EU

Paracetamol B. Braun (Paracetamol)

Paracetamol, the active ingredient in Paracetamol B. Braun, is an analgesic and antipyretic presented as an intravenous solution for intravenous use. It provides rapid reduction of pain and fever in adult and pediatric patients when oral administration is not feasible.

GNH India supplies Paracetamol B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, delivering EU‑quality products through regulated supply chains.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

Paracetamol is used to manage pain and fever by acting on the central nervous system.

  • Pain: provides rapid analgesic relief in acute and postoperative settings.
  • Fever: lowers elevated body temperature by resetting the hypothalamic set‑point.
  • Post‑operative pain: alleviates discomfort after surgical procedures.
  • Acute migraine: helps reduce headache intensity.
  • Dental pain: diminishes pain associated with dental interventions.

How It Works

  • Paracetamol exerts its analgesic and antipyretic actions primarily through inhibition of cyclooxygenase (COX) enzymes in the central nervous system, especially COX‑3, leading to reduced prostaglandin synthesis. This diminishes pain perception and lowers the hypothalamic temperature set‑point, while peripheral COX inhibition remains minimal, contributing to its safety profile.

Side Effects

Paracetamol may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: occasional gastrointestinal upset.
  • Injection site pain: discomfort at the infusion site.
  • Rash: mild skin eruption.
  • Elevated liver enzymes: transient increase in hepatic markers.

Serious or Rare Side Effects

  • Severe hepatotoxicity: potential liver failure with overdose.
  • Anaphylaxis: rare severe allergic reaction.
  • Stevens‑Johnson syndrome: rare severe skin disorder.

Precautions & Warnings

Paracetamol requires careful consideration in several clinical situations.

  • Dose adjustment in hepatic impairment: reduce dose or avoid in severe liver disease.
  • Avoid in known hypersensitivity to paracetamol: discontinue use immediately.
  • Monitor liver function tests: especially with prolonged therapy.
  • Use with caution in renal impairment: adjust dosing as needed.
  • Concurrent use with other hepatotoxic drugs: increase risk of liver injury.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Paracetamol can interact with several medications, necessitating monitoring.

Major Interactions (Avoid)

  • Concurrent use with other paracetamol‑containing products: risk of overdose.
  • Co‑administration with strong CYP450 inducers (e.g., rifampicin): may reduce efficacy.
  • Combination with warfarin: may increase bleeding risk.

Moderate Interactions (Monitor Closely)

  • Alcohol consumption: enhances hepatotoxic potential.
  • Use with other hepatotoxic agents (e.g., isoniazid): monitor liver function.
  • Concurrent NSAIDs: may increase renal risk.

Frequently Asked Questions

Paracetamol B. Braun is an intravenous formulation of paracetamol used in hospital settings to provide rapid relief of moderate to severe pain and to reduce fever when oral administration is not practical or contraindicated.

Paracetamol works by inhibiting cyclooxygenase enzymes, particularly COX‑3, in the central nervous system. This reduces the synthesis of prostaglandins that mediate pain and fever, thereby providing analgesic and antipyretic effects.

The appropriate dose is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and liver function. Healthcare professionals set the exact regimen according to established guidelines and individual needs.

Safety data for intravenous paracetamol during pregnancy and lactation are limited. Clinicians should evaluate the risk‑benefit ratio and consider alternative therapies when possible. Consultation with a specialist is recommended.

Enquiries are submitted via the product page on gnhindia.com, where the required quantity is entered. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Compared with IV non‑steroidal anti‑inflammatory drugs (e.g., ketorolac) or opioids, IV paracetamol offers analgesia and antipyresis with a lower risk of gastrointestinal bleeding and respiratory depression. It is often used as part of multimodal pain management to reduce opioid requirements.

The product should be stored at ambient temperature, below 25 °C, in its original packaging. It must be protected from light, moisture and extreme temperatures. Once opened, use according to the manufacturer’s stability guidelines.

Paracetamol B. Braun is given by intravenous infusion. The solution is diluted in an appropriate compatible fluid and administered over the recommended time period, typically 15 minutes, under aseptic conditions by qualified healthcare personnel.

The most serious adverse events include severe hepatotoxicity, especially with overdose, and rare hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome. Prompt recognition and discontinuation are essential if these occur.

Patients with known hypersensitivity to paracetamol, severe hepatic impairment, or those receiving other paracetamol‑containing products should avoid this medication. Caution is also advised in individuals with significant renal dysfunction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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