Product image of Paracetamol/Cafeine/Codeine Venipharm (Paracetamol, Codeine Phosphate Hemihydrate, Anhydrous Caffeine) supplied by GNH India

Paracetamol/Cafeine/Codeine Venipharm

Active Ingredient:
Paracetamol, Codeine Phosphate Hemihydrate, Anhydrous Caffeine
Origin:
EU

Paracetamol/Cafeine/Codeine Venipharm (Paracetamol, Codeine Phosphate Hemihydrate, Anhydrous Caffeine)

Paracetamol, the active ingredient in Paracetamol/Cafeine/Codeine Venipharm, is an analgesic and antipyretic presented as a combination tablet for oral use. It relieves moderate pain and reduces fever in adults. Codeine Phosphate Hemihydrate and anhydrous caffeine enhance analgesic effect and counteract fatigue.

GNH India supplies Paracetamol/Cafeine/Codeine Venipharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Venipharm

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Indications & Clinical Uses

Paracetamol/Caffeine/Codeine Venipharm is used for pain relief in several clinical contexts where combined analgesic and stimulant effects are beneficial.

  • Moderate acute pain: Provides effective relief when single‑component analgesics are insufficient.
  • Post‑operative pain: Helps manage pain after surgical procedures.
  • Headache and migraine relief: Reduces intensity of tension‑type headaches and migraine attacks.
  • Dental pain: Alleviates discomfort following dental extractions or procedures.
  • Musculoskeletal pain: Assists in controlling pain from strains, sprains and low‑back discomfort.

How It Works

  • Paracetamol acts centrally by inhibiting cyclo‑oxygenase enzymes, reducing prostaglandin synthesis and lowering the pain‑threshold set point. Codeine, an opioid agonist, binds to µ‑opioid receptors in the central nervous system, producing analgesia and mild sedation. Caffeine antagonises adenosine receptors, enhancing alertness and potentiating the analgesic effect of both paracetamol and codeine.

Side Effects

Paracetamol/Caffeine/Codeine Venipharm may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: Mild to moderate stomach upset.
  • Drowsiness: Increased sleepiness, especially after dose.
  • Constipation: Reduced bowel movements.
  • Dizziness: Light‑headed feeling.
  • Insomnia: Difficulty falling or staying asleep.
  • Loss of appetite: Reduced desire to eat.

Serious or Rare Side Effects

  • Respiratory depression: Slowed breathing, potentially life‑threatening.
  • Hepatotoxicity: Liver injury, especially with excess paracetamol.
  • Allergic reactions: Rash, itching, swelling, or anaphylaxis.
  • Seizures: Uncontrolled convulsions, rare but serious.
  • Severe hypotension: Marked drop in blood pressure.
  • Dependence or withdrawal: Signs of opioid dependence with prolonged use.

Precautions & Warnings

When prescribing Paracetamol/Caffeine/Codeine Venipharm, clinicians should consider patient‑specific factors and safety measures.

  • Liver function: Assess hepatic health before initiating therapy.
  • Respiratory conditions: Use caution in patients with asthma or COPD.
  • Opioid tolerance: Evaluate prior opioid exposure to avoid overdose.
  • Pregnancy and lactation: Limit use to situations where benefit outweighs risk.
  • Concomitant CNS depressants: Monitor for additive sedation.
  • Store below 25°C: Keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Paracetamol/Caffeine/Codeine Venipharm can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Other opioids: Risk of profound respiratory depression and overdose.
  • CNS depressants: Enhanced sedation and respiratory compromise when combined with benzodiazepines or barbiturates.
  • MAO inhibitors: Potential for hypertensive crisis with caffeine component.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: Paracetamol may increase bleeding risk.
  • Antiepileptics: May alter codeine metabolism, affecting analgesic efficacy.
  • CYP2D6 inhibitors: Reduce conversion of codeine to morphine, diminishing pain control.

Frequently Asked Questions

Paracetamol/Caffeine/Codeine Venipharm is a fixed‑dose combination tablet that provides analgesic and antipyretic relief for moderate acute pain, post‑operative discomfort, dental pain, tension‑type headaches and musculoskeletal aches when a single‑component product is insufficient.

Paracetamol reduces pain by inhibiting central cyclo‑oxygenase enzymes, lowering prostaglandin production and resetting the body’s pain threshold. Codeine adds opioid‑mediated analgesia through µ‑receptor activation, while caffeine blocks adenosine receptors, increasing alertness and boosting the overall pain‑relieving effect.

The specific dose and frequency are determined by the prescribing clinician based on the patient’s age, weight, pain severity and overall health status. Healthcare professionals tailor the regimen to achieve optimal relief while minimizing risk.

Paracetamol/Caffeine/Codeine Venipharm should only be used in pregnancy or lactation when the expected benefit outweighs potential risks. Codeine crosses the placenta and may cause neonatal respiratory depression; caffeine exposure is also discouraged. Consultation with a obstetrician or lactation specialist is essential.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with paracetamol alone, the Venipharm combination adds codeine for opioid‑mediated analgesia and caffeine for stimulant effects, delivering stronger pain control and reduced fatigue. This makes it suitable for moderate‑to‑severe pain where single‑ingredient therapy may be inadequate, but it also introduces additional safety considerations.

Store the tablets at or below 25 °C in a dry environment. Keep them in the original container, protect from moisture and direct sunlight, and ensure they are out of reach of children.

The medication is supplied as oral tablets intended for swallowing with water. It should be taken exactly as prescribed, typically with or without food, and patients should avoid crushing or chewing the tablets unless directed by a healthcare professional.

Serious risks include respiratory depression, especially in opioid‑naïve individuals or when combined with other depressants, hepatotoxicity from excess paracetamol, severe allergic reactions, and the potential for dependence or withdrawal with prolonged codeine use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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