Paracetamol/Coffeïne Aurobindo (Paracetamol, Caffeine)

Paracetamol/Caffeine is an analgesic and central nervous system stimulant that acts on pain and headache pathways.

• Headache: Provides relief from tension‑type and migraine‑associated headache pain.
• Fever: Reduces elevated body temperature in febrile conditions.
• Minor musculoskeletal pain: Alleviates discomfort from strains, sprains and backache.
• Dental pain: Helps manage pain following dental procedures.
• Cold‑related discomfort: Eases headache and body aches associated with common cold.

• Paracetamol reduces fever and relieves pain by inhibiting cyclo‑oxygenase enzymes in the central nervous system, decreasing prostaglandin synthesis. Caffeine acts as a non‑selective adenosine‑receptor antagonist, increasing neuronal firing and enhancing the analgesic effect of paracetamol through central nervous system stimulation.

Paracetamol/Caffeine may cause a range of adverse reactions.

Common Side Effects

• Nausea: Mild stomach upset may occur.
• Insomnia: Difficulty falling or staying asleep.
• Restlessness: Feeling of unease or jitteriness.
• Increased heart rate: Palpitation sensations.
• Gastrointestinal discomfort: Mild abdominal pain.

Serious or Rare Side Effects

• Allergic reaction: Rash, itching, swelling, or difficulty breathing.
• Liver toxicity: Elevated liver enzymes or hepatitis in overdose.
• Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Cardiac arrhythmia: Irregular heartbeat in susceptible individuals.
• Anaphylaxis: Life‑threatening systemic allergic response.

Paracetamol/Caffeine should be used with awareness of specific safety considerations.

• Liver function monitoring: Assess liver health before prolonged use.
• Pregnancy safety: Use only if clearly needed.
• Breastfeeding caution: Small amounts pass into milk; evaluate risk‑benefit.
• Drug interaction vigilance: Review concomitant medications for additive stimulant effects.
• Age restrictions: Avoid in children under 12 years without pediatric guidance.
• Store at ambient temperature: Keep in original packaging, protect from moisture and direct sunlight.

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